Posted in Biochemistry and molecular cell, biosynthetic, diabetic complications, glycolysis, hematopoiesis, hematopoietic stem cells, hyperglycaemia, Medium & Serums, microvascular, molecular cell biology, nonproliferating cells., Pcr Kits, Peptides, phenotypes, Recombinant Proteins, superoxide, Uncategorized, Vector & Virus, vitamins, Western Blot
Oxygen in stem cell biology: a critical component of the stem cell niche.
The defining hallmark of stem cells is their means to self-renew and keep multipotency. This capability is determined by the stability of advanced alerts in their microenvironment.
Low oxygen tensions (hypoxia) keep undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and in addition affect proliferation and cell-fate dedication.
Recent proof has recognized a broader spectrum of stem cells influenced by hypoxia that features most cancers stem cells and induced pluripotent stem cells. These findings have essential implications on our understanding of growth, illness, and tissue-engineering practices and moreover elucidate an added dimension of stem cell management inside the area of interest.
Antinuclear antibodies: diagnostic markers for autoimmune ailments and probes for cell biology.
- Cancers initially develop from regular cells that achieve the means to proliferate aberrantly and ultimately flip malignant. These cancerous cells then develop clonally into tumors and ultimately have the potential to metastasize.
 Anti-human TNF-alpha antibody |
| STJ15100115 |
St John's Laboratory |
250 µg |
EUR 367.00 |
|
Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in Flow cytometry and Western blot. |
|
Anti-human TNF-alpha antibody |
| STJ15100116 |
St John's Laboratory |
250 µg |
EUR 336.00 |
|
Description: We recommend MT25C5 as capture antibody in ELISA and ELISpot in combination with biotinylated detection antibody MT20D9. |
|
Anti-human TNF-alpha antibody |
| STJ15100117 |
St John's Laboratory |
250 µg |
EUR 367.00 |
|
Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in immunoassays such as ELISA and ELISpot. |
 Anti-TNF alpha APC |
| 1A-688-T025 |
ExBio |
25 tests |
EUR 140.00 |
|
Anti-TNF alpha APC |
| 1A-688-T100 |
ExBio |
100 tests |
EUR 240.00 |
 Anti-TNF alpha FITC |
| 1F-688-T025 |
ExBio |
25 tests |
EUR 122.00 |
|
Anti-TNF alpha FITC |
| 1F-688-T100 |
ExBio |
100 tests |
EUR 204.00 |
 Anti-TNF alpha PE |
| 1P-688-T025 |
ExBio |
25 tests |
EUR 140.00 |
|
Anti-TNF alpha PE |
| 1P-688-T100 |
ExBio |
100 tests |
EUR 240.00 |
 Anti-TNF alpha Purified |
| 11-687-C025 |
ExBio |
0.025 mg |
EUR 99.00 |
|
Anti-TNF alpha Purified |
| 11-687-C100 |
ExBio |
0.1 mg |
EUR 158.00 |
|
Anti-TNF alpha Purified |
| 11-688-C025 |
ExBio |
0.025 mg |
EUR 99.00 |
|
Anti-TNF alpha Purified |
| 11-688-C100 |
ExBio |
0.1 mg |
EUR 158.00 |
 anti- TNF alpha antibody |
| FNab08815 |
FN Test |
100µg |
EUR 585.00 |
|
Description: Antibody raised against TNF alpha |
 anti- TNF-alpha antibody |
| FNab08821 |
FN Test |
100µg |
EUR 585.00 |
|
Description: Antibody raised against TNF-alpha |
|
anti- TNF alpha antibody |
| FNab09822 |
FN Test |
100µg |
EUR 548.75 |
|
Description: Antibody raised against TNF alpha |
 Anti-TNF alpha Antibody |
| A00002-2 |
BosterBio |
100ug/vial |
EUR 294.00 |
|
Anti-TNF alpha Antibody |
| A00002-3 |
BosterBio |
100ug/vial |
EUR 294.00 |
) anti-TNF-alpha (2A9B9) |
| LF-MA30138 |
Abfrontier |
100 ul |
EUR 486.00 |
|
Description: Mouse Monoclonal to TNF-alpha |
|
Anti-TNF alpha Antibody |
| PB9010 |
BosterBio |
100ug/vial |
EUR 294.00 |
|
Anti-TNF alpha Antibody |
| PB9246 |
BosterBio |
100ug/vial |
EUR 294.00 |
|
Anti-TNF alpha Antibody |
| PA1079 |
BosterBio |
100ug/vial |
EUR 334.00 |
 Anti-TNF alpha antibody |
| STJ140123 |
St John's Laboratory |
150 µg |
EUR 408.00 |
|
Description: Goat polyclonal antibody to TNF alpha. TNF-alpha is produced by a variety of immune cells including NK cells, B cells, T cells and macrophages. It is multifunctional proinflammatory cytokine that belongs to the tumour necrosis factor (TNF) superfamily. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is involved in the regulation of several processes including lipid metabolism cell differentiation and proliferation, coagulation and apoptosis. It has been implicated in a variety of diseases, including cancer and autoimmune diseases. |
 Anti-TNF-alpha antibody |
| STJ96054 |
St John's Laboratory |
200 µl |
EUR 197.00 |
|
Description: TNF-alpha is a protein encoded by the TNF gene which is approximately 25,6 kDa. TNF-alpha is localised to the cell membrane. It is involved in PEDF induced signalling, TNFR1 pathway, allograft rejection and apoptosis modulation and signalling. It is a cytokine that is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, lipid metabolism, and coagulation. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-alpha is expressed in the blood, lung, spleen, liver and heart. Mutations in the TNF gene may result in psoriatic arthritis. STJ96054 was affinity purified. This polyclonal antibody binds to endogenous TNF-alpha. |
|
Anti-TNF-alpha antibody |
| STJ96516 |
St John's Laboratory |
200 µl |
EUR 197.00 |
|
Description: Rabbit polyclonal to TNF-alpha. |
|
Anti-TNF alpha antibody |
| STJ97488 |
St John's Laboratory |
200 µl |
EUR 197.00 |
|
Description: Rabbit polyclonal to TNF alpha. |
|
Anti-TNF alpha antibody |
| STJ97489 |
St John's Laboratory |
200 µl |
EUR 197.00 |
|
Description: Rabbit polyclonal to TNF alpha. |
|
Anti-TNF alpha antibody |
| STJ97493 |
St John's Laboratory |
200 µl |
EUR 197.00 |
|
Description: Mouse monoclonal to TNF alpha. |
|
Anti-TNF alpha antibody |
| STJ97494 |
St John's Laboratory |
200 µl |
EUR 197.00 |
|
Description: Mouse monoclonal to TNF alpha. |
 IgG #1 aff. Pure) Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #1 aff. Pure |
| TNFA11-M |
Alpha Diagnostics |
100 ug |
EUR 482.00 |
 IgG #2, aff. Pure) Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure |
| TNFA12-M |
Alpha Diagnostics |
100 ug |
EUR 482.00 |
 antiserum) Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE) antiserum |
| TACE11-S |
Alpha Diagnostics |
100 ul |
EUR 457.00 |
 IgG #2, aff. Pure (neutralzing)) Goat Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure (neutralzing) |
| TNFA13-A |
Alpha Diagnostics |
100 ul |
EUR 482.00 |
 Anti-human/monkey TNF-alpha antibody |
| STJ15100118 |
St John's Laboratory |
250 µg |
EUR 336.00 |
|
Description: This monoclonal antibody enables sensitive and specific detection of monkey TNF-α in immunoassays such as ELISA and ELISpot. |
|
Anti-human/monkey TNF-alpha antibody |
| STJ15100119 |
St John's Laboratory |
250 µg |
EUR 367.00 |
|
Description: This monoclonal antibody enables sensitive and specific detection of TNF-α in immunoassays such as ELISA and ELISpot, Flow cytometry, and Western blot. |
 Anti-mouse TNF alpha Antibody |
| RP1000 |
BosterBio |
100ug/vial |
EUR 334.00 |
 Anti-mouse TNF-alpha antibody |
| STJ15100113 |
St John's Laboratory |
250 µg |
EUR 336.00 |
|
Description: These monoclonal antibodies enable sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot. |
|
Anti-mouse TNF-alpha antibody |
| STJ15100114 |
St John's Laboratory |
250 µg |
EUR 367.00 |
|
Description: This monoclonal antibody enables sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot. |
) Anti-TNF alpha (M1-C4) |
| YF-MA10949 |
Abfrontier |
100 ug |
EUR 363.00 |
|
Description: Mouse monoclonal to TNF alpha |
) Anti-TNF alpha (M2-E3) |
| YF-MA15915 |
Abfrontier |
100 ug |
EUR 363.00 |
|
Description: Mouse monoclonal to TNF alpha |
 Human TNF-alpha ELISA Kit, 96 tests, Quantitative |
| 100-215-TNH |
Alpha Diagnostics |
1 kit |
EUR 482.00 |
 TNF alpha |
| GT15064 |
Neuromics |
100 ug |
EUR 526.00 |
|
TNF alpha |
| GT15113 |
Neuromics |
100 ug |
EUR 526.00 |
, IgG aff. Pure) Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE), IgG aff. Pure |
| TACE11-A |
Alpha Diagnostics |
100 ug |
EUR 482.00 |
, Human IgG4 Antibody) Anti-TNF alpha (Humicade), Human IgG4 Antibody |
| A1093-200 |
Biovision |
|
EUR 729.00 |
, Human IgG1 Antibody) Anti-TNF alpha (Infliximab), Human IgG1 Antibody |
| A1097-200 |
Biovision |
|
EUR 778.00 |
 Human anti TNF Alpha autoantibody ELISA kit |
| E01A2132-192T |
B-Gene |
192 tests |
EUR 1270.00 |
|
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|
Human anti TNF Alpha autoantibody ELISA kit |
| E01A2132-48 |
B-Gene |
1 plate of 48 wells |
EUR 520.00 |
|
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
|
Human anti TNF Alpha autoantibody ELISA kit |
| E01A2132-96 |
B-Gene |
1 plate of 96 wells |
EUR 685.00 |
|
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Rabbit Polyclonal antibody Anti-CRBN |
| Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349.00 |
 Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-20ug |
| 7124-RBM13-P0 |
EnQuireBio |
20ug |
EUR 233.00 |
 Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-100ug |
| 7124-RBM13-P1 |
EnQuireBio |
100ug |
EUR 428.00 |
 purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active) Recombinant (E.Coli) purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active |
| TNFA15-R-10 |
Alpha Diagnostics |
10 ug |
EUR 225.00 |
 Rapid Test cards, 10/pk) TruStrip RDT Humira/Adalimumab (anti-TNF-alpha) Rapid Test cards, 10/pk |
| 200-320-RDT |
Alpha Diagnostics |
1 pk |
EUR 293.00 |
 Human TNF alpha Protein |
| abx060828-005mg |
Abbexa |
0.05 mg |
EUR 551.00 |
 Human TNF-alpha antibody |
| 32809-05111 |
AssayPro |
150 ug |
EUR 261.00 |
 TNF-alpha, human recombinant |
| 1050-10 |
Biovision |
|
EUR 153.00 |
|
TNF-alpha, human recombinant |
| 1050-1000 |
Biovision |
|
EUR 1751.00 |
|
TNF-alpha, human recombinant |
| 1050-50 |
Biovision |
|
EUR 283.00 |
 Human TNF-alpha Antibody |
| 13101-05011 |
AssayPro |
150 ug |
EUR 217.00 |
 Anti-TNF alpha Purified Azide Free |
| 10-687-C100 |
ExBio |
0.1 mg |
EUR 158.00 |
) Anti-TNF alpha (1C3-A1-F4) |
| YF-MA15914 |
Abfrontier |
100 ug |
EUR 363.00 |
|
Description: Mouse monoclonal to TNF alpha |
 TNF alpha protein |
| 30R-3021 |
Fitzgerald |
20 ug |
EUR 433.00 |
|
Description: Purified recombinant TNF alpha protein |
|
TNF alpha protein |
| 30R-AT012 |
Fitzgerald |
50 ug |
EUR 490.00 |
|
Description: Purified recombinant Murine TNF alpha protein |
|
TNF alpha protein |
| 30R-AT013 |
Fitzgerald |
20 ug |
EUR 273.00 |
|
Description: Purified recombinant Rat TNF alpha protein |
|
TNF alpha protein |
| 30R-AT045 |
Fitzgerald |
1 mg |
EUR 1753.00 |
|
Description: Purified recombinant Human TNF alpha protein |
|
TNF alpha protein |
| 30R-AT046 |
Fitzgerald |
10 ug |
EUR 133.00 |
|
Description: Purified recombinant Human TNF alpha protein |
 TNF-alpha Antibody |
| 3052R-100 |
Biovision |
|
EUR 316.00 |
|
TNF-alpha Antibody |
| 3052R-30T |
Biovision |
|
EUR 146.00 |
|
TNF-alpha Antibody |
| 3053R-100 |
Biovision |
|
EUR 316.00 |
|
TNF-alpha Antibody |
| 3053R-30T |
Biovision |
|
EUR 146.00 |
|
TNF-alpha Antibody |
| 3054-100 |
Biovision |
|
EUR 316.00 |
|
TNF-alpha Antibody |
| 3054-30T |
Biovision |
|
EUR 146.00 |
|
TNF alpha protein |
| 30R-2188 |
Fitzgerald |
50 ug |
EUR 532.00 |
|
Description: Purified recombinant Human TNF alpha protein |
|
TNF alpha protein |
| 30R-2317 |
Fitzgerald |
50 ug |
EUR 352.00 |
|
Description: Purified recombinant Human TNF alpha protein |
|
TNF alpha protein |
| 30R-2402 |
Fitzgerald |
10 ug |
EUR 247.00 |
|
Description: Purified recombinant Human TNF alpha protein |
|
TNF alpha protein |
| 30R-2403 |
Fitzgerald |
10 ug |
EUR 247.00 |
|
Description: Purified recombinant Human TNF alpha protein |
 TNF alpha antibody |
| 10R-6647 |
Fitzgerald |
50 ug |
EUR 154.00 |
|
Description: Mouse monoclonal TNF alpha antibody |
|
TNF alpha antibody |
| 10R-6648 |
Fitzgerald |
50 ug |
EUR 154.00 |
|
Description: Mouse monoclonal TNF alpha antibody |
- A central query in most cancers biology is, which cells could be reworked to type tumors? Recent research elucidated the presence of most cancers stem cells which have the unique means to regenerate tumors.
- These most cancers stem cells share many traits with regular stem cells, together with self-renewal and differentiation. With the rising proof that most cancers stem cells exist in a big range of tumors, it’s changing into more and more essential to grasp the molecular mechanisms that regulate self-renewal and differentiation as a result of corruption of genes concerned in these pathways seemingly participates in tumor development.
- This new paradigm of oncogenesis has been validated in a rising record of tumors. Studies of regular and most cancers stem cells from the identical tissue have make clear the ontogeny of tumors.
- That signaling pathways equivalent to Bmi1 and Wnt have related results in regular and most cancers stem cell self-renewal means that widespread molecular pathways regulate each populations. Understanding the biology of most cancers stem cells will contribute to the identification of molecular targets essential for future therapies.
Toward an understanding of NKT cell biology: progress and paradoxes.
- Natural killer T (NKT) cells represent a conserved T cell sublineage with distinctive properties, together with reactivity for a artificial glycolipid introduced by CD1d, expression of an invariant T cell antigen receptor (TCR) alpha chain, and weird necessities for thymic choice.
- They quickly produce many cytokines after stimulation and thus affect various immune responses and pathogenic processes. Because of intensive analysis effort, now we have realized a lot about elements selling the growth and survival of NKT cells, regulation of their cytokine manufacturing, and the means by which they affect dendritic cells and different cell sorts.
Product not found
- Despite this progress, data of the pure antigen(s) they acknowledge and their physiologic position stay incomplete. The activation of NKT cells paradoxically can lead both to suppression or stimulation of immune responses, and we can’t predict which can happen. Despite this uncertainty, many investigators are hopeful that immune therapies could be developed based mostly on NKT cell stimulation.
- The discovery of mouse embryonic stem (ES) cells >20 years in the past represented a main advance in biology and experimental drugs, because it enabled the routine manipulation of the mouse genome.
- Along with the capability to induce genetic modifications, ES cells offered the foundation for establishing an in vitro mannequin of early mammalian growth and represented a putative new supply of differentiated cell sorts for cell alternative remedy.
- While ES cells have been used extensively for creating mouse mutants for greater than a decade, their software as a mannequin for developmental biology has been restricted and their use in cell alternative remedy stays a purpose for a lot of in the subject.
- Recent advances in our understanding of ES cell differentiation, detailed in this evaluation, have offered new insights important for establishing ES cell-based developmental fashions and for the technology of clinically related populations for cell remedy.
Ellie
Anti-TNF-Alpha antibody 
Anti-Mouse TNF-alpha antibody 
TNF-alpha 
TNF-alpha/TNFSF2, Human 
