Posted in Biochemistry and molecular cell, biosynthetic, diabetic complications, glycolysis, hematopoiesis, hematopoietic stem cells, hyperglycaemia, Medium & Serums, microvascular, molecular cell biology, nonproliferating cells., Pcr Kits, Peptides, phenotypes, Recombinant Proteins, superoxide, Uncategorized, Vector & Virus, vitamins, Western Blot
Embryonic stem cell differentiation: emergence of a new era in biology and medicine.
The conversion of exogenous and endogenous proteins into immunogenic peptides acknowledged by T lymphocytes entails a collection of proteolytic and different enzymatic occasions culminating in the formation of peptides sure to MHC class I or class II molecules. Although the biochemistry of these occasions has been studied in element, solely in the previous few years has comparable info begun to emerge describing the mobile context in which these occasions happen.
This evaluate thus concentrates on the properties of antigen-presenting cells, particularly these elements of their total group, regulation, and intracellular transport that each facilitate and modulate the processing of protein antigens.
Emphasis is positioned on dendritic cells and the specializations that assist account for his or her marked effectivity at antigen processing and presentation each in vitro and, importantly, in vivo. How dendritic cells deal with antigens is more likely to be as necessary a determinant of immunogenicity and tolerance as is the character of the antigens themselves.
- Several many years of analysis have sought to characterize tumor cell metabolism in the hope that tumor-specific actions might be exploited to deal with most cancers. Having originated from Warburg’s seminal statement of cardio glycolysis in tumor cells, most of this consideration has centered on glucose metabolism.
- However, because the 1950s most cancers biologists have additionally acknowledged the significance of glutamine (Q) as a tumor nutrient.
13 mm Diameter Tapped Titanium Tip |
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Biologics |
- |
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13 mm Diameter Solid Titanium Tip |
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Biologics |
- |
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19 mm Diameter Tapped Titanium Tip |
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Biologics |
- |
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19 mm Diameter Solid Titanium Tip |
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Biologics |
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25 mm Diameter Tapped Titanium Tip |
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Biologics |
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25 mm Diameter Solid Titanium Tip |
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Biologics |
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Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip |
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Biologics |
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Description: use with corresponding Tapped Tips and Tapped Extender Tips |
Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip |
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Biologics |
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Description: use with corresponding Tapped Tips and Tapped Extender Tips |
Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip |
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Biologics |
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Description: use with corresponding Tapped Tips and Tapped Extender Tips |
Titanium Cup Tip, 250 ml |
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Biologics |
- |
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Description: includes Interface Washers |
Microtube Tray, 8 Position (for 250 ml Cup Tip) |
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Biologics |
- |
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Description: includes Interface Washers |
Continuous Flow Chamber |
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Biologics |
- |
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Description: includes Interface Washers |
Interface Washers 1.5” Diameter, 5/Pkg |
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Biologics |
- |
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13 mm Diameter Solid Titanium Extender Tip |
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Biologics |
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13 mm Diameter Tapped Titanium Extender Tip |
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Biologics |
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19 mm Diameter Solid Titanium Extender Tip |
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Biologics |
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19 mm Diameter Tapped Titanium Extender Tip |
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Biologics |
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25 mm Diameter Solid Titanium Extender Tip |
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Biologics |
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25 mm Diameter Tapped Titanium Extender Tip |
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Biologics |
- |
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KoldPod, 1.5ml Micro Tube |
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Biologics |
- |
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Description: Thermo conductive tube pods |
KoldPod, 15ml Conical Tube |
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Biologics |
- |
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Description: Thermo conductive tube pods |
KoldPod, 50ml Conical Tube |
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Biologics |
- |
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Description: Thermo conductive tube pods |
Model 150 V/T Ultrasonic Homogenizer |
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Biologics |
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Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing. |
Model 300 V/T Ultrasonic Homogenizer |
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Biologics |
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Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample. |
SONABOZ Sound Abating Chamber |
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Biologics |
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Description: Reduces cavitational sound emitted during processing. |
Model 3000 Ultrasonic Homogenizer |
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Biologics |
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Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample. |
Model 3000MP Ultrasonic Homogenizer |
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Biologics |
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Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing. |
OMNICON® Zone Reader, 210-240V/50-60Hz |
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Biologics |
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Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media. |
OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz |
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Biologics |
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Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample. |
Peni Cylinder Dispenser with Manual Hopper |
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Biologics |
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Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish. |
Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz |
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Biologics |
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Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection. |
Stainless Steel Peni Cylinder with Flat Face |
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Biologics |
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Description: sold in packages of 100 pieces |
Stainless Steel Peni Cylinder with Chamfered Face |
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Biologics |
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Description: sold in packages of 100 pieces |
Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA) |
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Alpha Diagnostics |
- |
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Alpha-Bungarotoxin, CF®405S, 500 ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-bungarotoxin, CF405s |
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Cusabio |
- |
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Description: Minimum order quantity: 1 unit of 500uG |
Alpha-Bungarotoxin, CF®405S, 500 ug |
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Biotium |
- |
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Alpha-Bungarotoxin, CF®405S 100ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®680R, 500 ug |
9-00003 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®680R, 500 ug |
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Biotium |
- |
Ask for price |
Alpha-Bungarotoxin, CF®680R 100ug |
9-00003 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®640R, 500 ug |
9-00004 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®640R, 500 ug |
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Biotium |
- |
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Alpha-Bungarotoxin, CF®640R 100ug |
9-00004 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®488A, 500 ug |
9-00005 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®488A, 500 ug |
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Biotium |
- |
Ask for price |
Alpha-Bungarotoxin CF®488A 100ug |
9-00005 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®568, 500 ug |
9-00006 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®568, 500 ug |
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Biotium |
- |
Ask for price |
Alpha-Bungarotoxin, CF®568 100ug |
9-00006 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®594, 500 ug |
9-00007 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®594, 500 ug |
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Biotium |
- |
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Alpha-Bungarotoxin CF®594 100ug |
9-00007 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®633, 500 ug |
9-00009 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®633, 500 ug |
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Biotium |
- |
Ask for price |
Alpha-Bungarotoxin, CF®633 100ug |
9-00009 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
SARS-CoV-2 Indicator Cell Line for RNA Replication - GFP Reporter only |
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IBT Bioservices |
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Description: SARS-CoV-2 GFP reporter cell line using HEK293T (ACE2/TMPRSS2) cells |
Alpha-Bungarotoxin, 1 mg |
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Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, 1 mg |
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Biotium |
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Fluorescein-Alpha-Bungarotoxin, 500 ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Fluorescein-Alpha-Bungarotoxin, 500 ug |
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Biotium |
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Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug |
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Biotium |
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Fluorescein-alpha-bungarotoxin, 10x50ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Fluorescein-alpha-bungarotoxin, 10x50ug |
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Biotium |
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Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug |
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Biotium |
- |
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Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug |
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Biotium |
- |
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Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug |
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Biotium |
- |
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Biotin-XX-A-Bungarotoxin, 500 ug |
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Biotium |
- |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Biotin-XX-A-Bungarotoxin, 500 ug |
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Biotium |
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Alpha-Bungarotoxin, CF®555, 500 ug |
9-00018 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Alpha-Bungarotoxin, CF®555, 500 ug |
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Biotium |
- |
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Alpha-Bungarotoxin, CF®555 100ug |
9-00018 |
Biotium |
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus) |
Biotin-cAMP, 1 mg |
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Biotium |
- |
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Description: N/A |
Biotin-cAMP, 1 mg |
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Biotium |
- |
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Description: N/A |
Biotin-cAMP, 50 ug |
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Biotium |
- |
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Biotin-cGMP, 1 mg |
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Biotium |
- |
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Description: N/A |
Biotin-cGMP, 1 mg |
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Biotium |
- |
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Description: N/A |
Biotin-cGMP, 20x50 ug |
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Biotium |
- |
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Cyanine 644-cAMP, 1 mg |
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Biotium |
- |
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Description: N/A |
Cyanine 644-cAMP, 1 mg |
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Biotium |
- |
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Description: N/A |
Cyanine 644-cAMP, 20x50 ug |
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Biotium |
- |
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Fluorescein Methotrexate, Triammonium Salt, 1 mg |
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Biotium |
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Description: N/A |
- Glutamine contributes to primarily each core metabolic activity of proliferating tumor cells: it participates in bioenergetics, helps cell defenses towards oxidative stress and enhances glucose metabolism in the manufacturing of macromolecules.
- The curiosity in glutamine metabolism has been heightened additional by the current findings that c-myc controls glutamine uptake and degradation, and that glutamine itself exerts affect over a quantity of signaling pathways that contribute to tumor development.
- These observations are stimulating a renewed effort to grasp the regulation of glutamine metabolism in tumors and to develop methods to focus on glutamine metabolism in most cancers. In this examine we evaluate the protean roles of glutamine in most cancers, each in the direct assist of tumor development and in mediating some of the advanced results on whole-body metabolism which can be attribute of tumor development.
Mesenchymal stem cells derived from dental tissues vs. these from different sources: their biology and function in regenerative drugs.
- To date, 5 totally different human dental stem/progenitor cells have been remoted and characterised: dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous enamel (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAP), and dental follicle progenitor cells (DFPCs). These postnatal populations have mesenchymal-stem-cell-like (MSC) qualities, together with the capability for self-renewal and multilineage differentiation potential.
- MSCs derived from bone marrow (BMMSCs) are succesful of giving rise to numerous lineages of cells, akin to osteogenic, chondrogenic, adipogenic, myogenic, and neurogenic cells. The dental-tissue-derived stem cells are remoted from specialised tissue with potent capacities to distinguish into odontogenic cells. However, additionally they have the power to present rise to different cell lineages much like, however totally different in efficiency from, that of BMMSCs.
This article will evaluate the isolation and characterization of the properties of totally different dental MSC-like populations in comparability with these of different MSCs, akin to BMMSCs. Important points in stem cell biology, akin to stem cell area of interest, homing, and immunoregulation, may even be mentioned.
- Among the membrane compartments of a cell, vesicles often called “caveolae” have lengthy defied useful characterization. However, because the identification of a household of proteins termed “caveolins“, that type and reside in caveolae, a higher understanding has emerged.
- It is now clear that caveolae don’t merely play a singular function in the cell, however are caveolaein nature-serving to modulate many mobile capabilities. The function of this evaluate is to explicate what is understood about caveolins/caveolae and spotlight rising areas of caveolaeresearch.
Human IL-19 |
MBS691676-5x001mg |
MyBiosource |
5x0.01mg |
EUR 1725 |
IL-19, Human |
MBS8575180-0005mg |
MyBiosource |
0.005mg |
EUR 245 |
IL-19, Human |
MBS8575180-5x0005mg |
MyBiosource |
5x0.005mg |
EUR 940 |
Interleukin-19 (IL-19) Human |
GWB-404DB0 |
GenWay Biotech |
0.01 mg |
Ask for price |
Anti-Human IL-19 Antibody |
101-M495 |
ReliaTech |
100 µg |
EUR 399 |
Description: Human Interleukin 19 (IL-19) is a member of the IL-10 family of related cytokines. IL-19 contains seven helices and is secreted as a 35 kDa glycosylated monomer. IL-19 expression has been observed in keratinocytes and monocytes. IL-19 binds a receptor complex consisting of IL-20R alpha and the IL-20 R beta. This receptor complex is also shared by IL-20 and IL-24. |
Anti-Human IL-19 Antibody |
102-P235 |
ReliaTech |
100 µg |
EUR 245.7 |
Description: Human Interleukin 19 (IL-19) is a member of the IL-10 family of related cytokines. IL-19 contains seven helices and is secreted as a 35 kDa glycosylated monomer. IL-19 expression has been observed in keratinocytes and monocytes. IL-19 binds a receptor complex consisting of IL-20R alpha and the IL-20 R beta. This receptor complex is also shared by IL-20 and IL-24. |
IL-19, human recombinant |
4545-10 |
Biovision |
each |
EUR 385.2 |
IL-19, human recombinant |
4545-1000 |
Biovision |
each |
EUR 9325.2 |
Recombinant Human IL-19 |
HEILP-1901 |
Cyagen |
10ug |
Ask for price |
Recombinant Human IL-19 |
MBS258255-0005mg |
MyBiosource |
0.005mg |
EUR 305 |
Recombinant Human IL-19 |
MBS258255-5x0005mg |
MyBiosource |
5x0.005mg |
EUR 1210 |
IL-19 (human), (recombinant) |
MBS567245-001mg |
MyBiosource |
0.01mg |
EUR 395 |
IL-19 (human), (recombinant) |
MBS567245-01mg |
MyBiosource |
0.1mg |
EUR 1810 |
IL-19 (human), (recombinant) |
MBS567245-5x01mg |
MyBiosource |
5x0.1mg |
EUR 8075 |
Recombinant Human IL-19 |
MBS7611602-005mg |
MyBiosource |
0.05mg |
EUR 345 |
Recombinant Human IL-19 |
MBS7611602-02mg |
MyBiosource |
0.2mg |
EUR 635 |
Recombinant Human IL-19 |
MBS7611602-1mg |
MyBiosource |
1mg |
EUR 1800 |
Recombinant Human IL-19 |
MBS7611602-5x1mg |
MyBiosource |
5x1mg |
EUR 6955 |
Recombinant Human IL-19 |
P1130-.01 |
ApexBio |
10ug |
EUR 272.8 |
Description: Peptides & Proteins|Recombinant Proteins |
Recombinant Human IL-19 |
P1130-.1 |
ApexBio |
100ug |
EUR 1561.6 |
Description: Peptides & Proteins|Recombinant Proteins |
Recombinant Human IL-19 |
P1130-.5 |
ApexBio |
500ug |
EUR 3503.2 |
Description: Peptides & Proteins|Recombinant Proteins |
Recombinant Human IL-19 |
PH2016-.01 |
ApexBio |
10ug |
EUR 224 |
Description: Peptides & Proteins|Recombinant Proteins |
Recombinant Human IL-19 |
PH2016-.1 |
ApexBio |
10X10ug |
EUR 848 |
Description: Peptides & Proteins|Recombinant Proteins |
anti- IL-19 antibody |
FNab04233 |
FN Test |
100µg |
EUR 702 |
Description: Antibody raised against IL-19 |
anti- IL-19 antibody |
FNab04234 |
FN Test |
100µg |
EUR 702 |
Description: Antibody raised against IL-19 |
anti- IL-19 antibody |
FNab04235 |
FN Test |
100µg |
EUR 702 |
Description: Antibody raised against IL-19 |
Anti-IL-19 Antibody |
A04434 |
BosterBio |
100ul |
EUR 399 |
Description: Boster Bio Anti-IL-19 Antibody catalog # A04434. Tested in IHC, WB applications. This antibody reacts with Human, Rat. |
Anti-IL-19 Antibody |
ER1802-1 |
HUABIO |
100ul |
EUR 189 |
Description: Interleukin 19 (IL-19) is an immunosuppressive protein that belongs to the IL-10 cytokine subfamily. IL-19 is associated with broad functions across inflammation, cell development, viral responses, and lipid metabolism. As an immunosuppressive cytokine, IL-19 promotes the Th2 (regulatory) T-cell response which supports an anti-inflammatory lymphocyte phenotype, dampens the Th1 T-cell response and inflammatory cytokine secretion (IFNγ), increases IL-10 (anti-inflammatory) expression in peripheral blood mononuclear cells (PBMC), and inhibits the production of immunoglobulin G (IgG) from B cells. |
Anti-IL-19 Antibody |
MBS8248234-003mL |
MyBiosource |
0.03mL |
EUR 185 |
Anti-IL-19 Antibody |
MBS8248234-01mL |
MyBiosource |
0.1mL |
EUR 255 |
Anti-IL-19 Antibody |
MBS8248234-02mL |
MyBiosource |
0.2mL |
EUR 335 |
Anti-IL-19 Antibody |
MBS8248234-5x02mL |
MyBiosource |
5x0.2mL |
EUR 1420 |
Anti-IL-19 antibody |
STJ98773 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to IL-19. |
Human IL-19 -Interleukin 19- CLIA Kit |
E-CL-H0212-24Tests |
Elabscience Biotech |
24 Tests |
EUR 180 |
Description: Sandwich |
Human IL-19 -Interleukin 19- CLIA Kit |
E-CL-H0212-48Tests |
Elabscience Biotech |
48 Tests |
EUR 546 |
Description: Sandwich |
Human IL-19 -Interleukin 19- CLIA Kit |
E-CL-H0212-96Tests |
Elabscience Biotech |
96 Tests |
EUR 682 |
Description: Sandwich |
Human IL-19 -Interleukin 19- CLIA Kit |
E-CL-H0212-96Tests10 |
Elabscience Biotech |
96 Tests *10 |
EUR 6820 |
Description: Sandwich |
Human IL-19 -Interleukin 19- CLIA Kit |
E-CL-H0212-96Tests5 |
Elabscience Biotech |
96 Tests *5 |
EUR 3410 |
Description: Sandwich |
Human IL-19 (Interleukin 19) CLIA Kit |
MBS2533100-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2565 |
Human IL-19 (Interleukin 19) CLIA Kit |
MBS2533100-96Tests |
MyBiosource |
96Tests |
EUR 560 |
Human Interleukin 19, IL-19 ELISA Kit |
MBS706147-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 5325 |
Human Interleukin 19, IL-19 ELISA Kit |
MBS706147-24StripWellsLIMIT1 |
MyBiosource |
24-Strip-Wells(LIMIT1) |
EUR 275 |
Human Interleukin 19, IL-19 ELISA Kit |
MBS706147-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 480 |
Human Interleukin 19, IL-19 ELISA Kit |
MBS706147-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2795 |
Human Interleukin 19, IL-19 ELISA Kit |
MBS706147-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 675 |
Human Interleukin 19(IL-19)ELISA Kit |
CSB-E17323h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 19 (IL-19) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Interleukin 19(IL-19)ELISA Kit |
1-CSB-E17323h |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 5 plates of 96 wells each
- 1 plate of 96 wells
- 10 plates of 96 wells each
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 19(IL-19) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
- Membrane lateral heterogeneity is accepted as a requirement for the operate of organic membranes and the notion of lipid rafts offers specificity to this broad idea.
- However, the lipid raft subject is now at a technical deadlock as a result of the bodily instruments to check organic membranes as a liquid that’s ordered in house and time are nonetheless being developed.
- This has result in a disconnection between the idea of lipid rafts as derived from biochemical and biophysical assays and their existence in the cell. Here, we evaluate the idea of lipid rafts because it has emerged from the examine of artificial membranes with the truth of lateral heterogeneity in organic membranes.
- Further software of present instruments and the event of new instruments are wanted to grasp the dynamic heterogeneity of organic membranes.