Translating cell biology into therapeutic advances in Alzheimer’s disease.

Studies of the molecular foundation of Alzheimer’s illness exemplify the more and more blurred distinction between primary and utilized biomedical analysis. The 4 genes up to now implicated in familial Alzheimer’s illness have every been proven to raise mind ranges of the self-aggregating amyloid-beta protein, main step by step to profound neuronal and glial alteration, synaptic loss and dementia. Progress in understanding this cascade has helped to determine particular therapeutic targets and gives a mannequin for elucidating different neurodegenerative problems.

 

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Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative motion.

 

  • The double-stranded RNA-dependent protein kinase PKR is a vital mediator of the antiproliferative and antiviral results exerted by interferons.

 

  • Not solely is PKR an effector molecule on the mobile response to double-stranded RNA, nevertheless it additionally integrates indicators in response to Toll-like receptor activation, progress components, and numerous mobile stresses.

Recombinant Caenorhabditis Elegans clec-159 Protein (aa 1-207)

VAng-Ly3238-1mgEcoli 1 mg (E. coli)
EUR 4216.8
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 159 (clec-159), recombination protein.

Recombinant Caenorhabditis Elegans clec-159 Protein (aa 1-207)

VAng-Ly3238-500gEcoli 500 µg (E. coli)
EUR 3013.2
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 159 (clec-159), recombination protein.

Recombinant Caenorhabditis Elegans clec-159 Protein (aa 1-207)

VAng-Ly3238-50gEcoli 50 µg (E. coli)
EUR 2056.8
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 159 (clec-159), recombination protein.

Recombinant Caenorhabditis Elegans clec-161 Protein (aa 21-862)

VAng-Ly3239-inquire inquire Ask for price
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 161 (clec-161), partial, recombination protein.

Recombinant Caenorhabditis Elegans clec-162 Protein (aa 18-313)

VAng-Ly3240-1mgEcoli 1 mg (E. coli)
EUR 4893.6
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 162 (clec-162), recombination protein.

Recombinant Caenorhabditis Elegans clec-162 Protein (aa 18-313)

VAng-Ly3240-500gEcoli 500 µg (E. coli)
EUR 3474
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 162 (clec-162), recombination protein.

Recombinant Caenorhabditis Elegans clec-162 Protein (aa 18-313)

VAng-Ly3240-50gEcoli 50 µg (E. coli)
EUR 2370
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 162 (clec-162), recombination protein.

Recombinant Caenorhabditis Elegans clec-91 Protein (aa 22-225)

VAng-Ly3241-1mgEcoli 1 mg (E. coli)
EUR 4200
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 91 (clec-91), recombination protein.

Recombinant Caenorhabditis Elegans clec-91 Protein (aa 22-225)

VAng-Ly3241-500gEcoli 500 µg (E. coli)
EUR 2997.6
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 91 (clec-91), recombination protein.

Recombinant Caenorhabditis Elegans clec-91 Protein (aa 22-225)

VAng-Ly3241-50gEcoli 50 µg (E. coli)
EUR 2040
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 91 (clec-91), recombination protein.

PE anti-human CD301 (CLEC10A)

E16FHP301-025 25 tests
EUR 541.67
Description: Available in various conjugation types.

PE anti-human CD301 (CLEC10A)

E16FHP301-100 100 tests
EUR 1278.33
Description: Available in various conjugation types.

APC anti-human CD301 (CLEC10A)

E16FHA301-025 25 tests
EUR 563.33
Description: Available in various conjugation types.

APC anti-human CD301 (CLEC10A)

E16FHA301-100 100 tests
EUR 1343.33
Description: Available in various conjugation types.

Human CLEC12A / MICL / CLL-1 Protein, His Tag

CLA-H5245 50ug
EUR 3092.3
Description: Human CLEC12A, His Tag (CLA-H5245) is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).

Purified anti-human CD301 (CLEC10A)

E16FHU301-025U 25 μg
EUR 325
Description: Available in various conjugation types.

Purified anti-human CD301 (CLEC10A)

E16FHU301-100U 100 μg
EUR 758.33
Description: Available in various conjugation types.

Human CLEC2B Antibody

33430-05111 150 ug
EUR 313.2

Human CLEC4E Antibody

32522-05111 150 ug
EUR 313.2

CLEC10A sgRNA CRISPR Lentivector (Human) (Target 1)

K0463402 1.0 ug DNA
EUR 184.8

CLEC11A sgRNA CRISPR Lentivector (Human) (Target 1)

K0463502 1.0 ug DNA
EUR 184.8

CLEC12A sgRNA CRISPR Lentivector (Human) (Target 1)

K0463602 1.0 ug DNA
EUR 184.8

CLEC12B sgRNA CRISPR Lentivector (Human) (Target 1)

K0463702 1.0 ug DNA
EUR 184.8

CLEC14A sgRNA CRISPR Lentivector (Human) (Target 1)

K0463802 1.0 ug DNA
EUR 184.8

CLEC16A sgRNA CRISPR Lentivector (Human) (Target 1)

K0463902 1.0 ug DNA
EUR 184.8

CLEC17A sgRNA CRISPR Lentivector (Human) (Target 1)

K0464002 1.0 ug DNA
EUR 184.8

CLEC18A sgRNA CRISPR Lentivector (Human) (Target 1)

K0464102 1.0 ug DNA
EUR 184.8

CLEC18B sgRNA CRISPR Lentivector (Human) (Target 1)

K0464202 1.0 ug DNA
EUR 184.8

CLEC18C sgRNA CRISPR Lentivector (Human) (Target 1)

K0464302 1.0 ug DNA
EUR 184.8

Nori® Human Dectin-1/CLEC7A ELISA Kit

GR111344 96-well
EUR 461

Recombinant Human CLEC7A/Dectin-1/CD369 Protein

RP01523 20μg
EUR 162.5

Human CLEC12A / MICL / CLL-1 Protein, Fc Tag (MALS verified)

CLA-H5266 50ug
EUR 3242.1
Description: Human CLEC12A, Fc Tag (CLA-H5266) is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).

FITC-Labeled Human CLEC12A / MICL / CLL-1 Protein, His Tag

CLA-HF247 25ug
EUR 2471.7
Description: FITC-Labeled Human CLEC12A, His Tag (CLA-HF247) is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2). It is the FITC labeled form of Human CLEC12A, His Tag (CLA-H5245).

anti- CLEC11A antibody

FNab01746 100µg
EUR 606.3
Description: Antibody raised against CLEC11A

anti- CLEC12B antibody

FNab01747 100µg
EUR 658.5
Description: Antibody raised against CLEC12B

anti- CLEC14A antibody

FNab01748 100µg
EUR 658.5
Description: Antibody raised against CLEC14A

anti- CLEC18A antibody

FNab01749 100µg
EUR 658.5
Description: Antibody raised against CLEC18A

CLEC1A sgRNA CRISPR Lentivector (Human) (Target 1)

K0461402 1.0 ug DNA
EUR 184.8

CLEC1B sgRNA CRISPR Lentivector (Human) (Target 1)

K0461502 1.0 ug DNA
EUR 184.8

CLEC2A sgRNA CRISPR Lentivector (Human) (Target 1)

K0461602 1.0 ug DNA
EUR 184.8

CLEC2B sgRNA CRISPR Lentivector (Human) (Target 1)

K0461702 1.0 ug DNA
EUR 184.8

CLEC2D sgRNA CRISPR Lentivector (Human) (Target 1)

K0461802 1.0 ug DNA
EUR 184.8

CLEC2L sgRNA CRISPR Lentivector (Human) (Target 1)

K0461902 1.0 ug DNA
EUR 184.8

CLEC3A sgRNA CRISPR Lentivector (Human) (Target 1)

K0462002 1.0 ug DNA
EUR 184.8

CLEC3B sgRNA CRISPR Lentivector (Human) (Target 1)

K0462102 1.0 ug DNA
EUR 184.8

CLEC4A sgRNA CRISPR Lentivector (Human) (Target 1)

K0462202 1.0 ug DNA
EUR 184.8

CLEC4C sgRNA CRISPR Lentivector (Human) (Target 1)

K0462302 1.0 ug DNA
EUR 184.8

CLEC4D sgRNA CRISPR Lentivector (Human) (Target 1)

K0462402 1.0 ug DNA
EUR 184.8
  • In this evaluation, we offer an in depth image on how signaling downstream of PKR unfolds and what are the last word penalties for the cell destiny. PKR activation impacts each transcription and translation.

 

  • PKR phosphorylation of the alpha subunit of eukaryotic initiation issue 2 outcomes in a blockade on translation initiation. However, PKR can’t keep away from the interpretation of some mobile and viral mRNAs bearing particular options in their 5′ untranslated areas.

 

  • In addition, PKR impacts numerous transcriptional components resembling interferon regulatory issue 1, STATs, p53, activating transcription issue 3, and NF-kappaB. In specific, how PKR triggers a cascade of occasions involving IKK phosphorylation of IkappaB and NF-kappaB nuclear translocation has been intensively studied.

 

  • At the mobile and organism ranges PKR exerts antiproliferative results, and it’s a key antiviral agent. Some extent of convergence in each results is that PKR activation outcomes in apoptosis induction.

 

  • The extent and power of the antiviral motion of PKR are clearly understood by the findings that unrelated viral proteins of animal viruses have advanced to inhibit PKR motion by utilizing numerous methods. The case for the pathological penalties of the antiproliferative motion of PKR is much less understood, however therapeutic methods geared toward focusing on PKR are starting to supply promising outcomes.

 

  • Tetrazolium salts have change into among the most generally used instruments in cell biology for measuring the metabolic exercise of cells starting from mammalian to microbial origin.

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-MP004959HU1
  • EUR 327.60
  • EUR 1052.40
  • EUR 453.60
  • EUR 786.00
  • 100ug
  • 1MG
  • 200ug
  • 500ug
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80),partial expressed in Mammalian cell

APC anti-human CD80

E16FHA080-025 25 tests
EUR 411.67
Description: Available in various conjugation types.

APC anti-human CD80

E16FHA080-100 100 tests
EUR 975
Description: Available in various conjugation types.

FITC anti-human CD80

E16FHF080-025 25 tests
EUR 222.33
Description: Available in various conjugation types.

FITC anti-human CD80

E16FHF080-050 50 tests
EUR 317.67
Description: Available in various conjugation types.

FITC anti-human CD80

E16FHF080-100 100 Tests
EUR 496
Description: Available in various conjugation types.

Biotin anti-human CD80

E16FHB080-100U 100 μg
EUR 693.33
Description: Available in various conjugation types.

Purified anti-human CD80

E16FHU080-100U 100 μg
EUR 190.67
Description: Available in various conjugation types.

Purified anti-human CD80

E16FHU080-500U 500 μg
EUR 572
Description: Available in various conjugation types.

Mouse Anti Human Cd80 Monoclonal Antibody,RPE

CABT-46705MH 25 TEST
EUR 514.8

Mouse Anti Human Cd80 Monoclonal Antibody,FITC

CABT-46701MH 0.1 mg
EUR 795.6

anti- CD80 antibody

FNab09813 100µg
EUR 658.5
Description: Antibody raised against CD80

anti- CD80 antibody

FNab01500 100µg
EUR 658.5
Description: Antibody raised against CD80

Human CD80/ T-lymphocyte activation antigen CD80 ELISA Kit

E0441Hu 1 Kit
EUR 675.6

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EH0088 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 46.9pg/ml

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EKF57017-48T 48T
EUR 396.9

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EKF57017-5x96T 5x96T
EUR 2693.25

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EKF57017-96T 96T
EUR 567

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

E39EH0088 96T
EUR 595

Mouse Human CD80

E2790169 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Anti Human Cd80 Monoclonal Antibody,RPE-Cy5

CABT-46707MH 2ml
EUR 920.4

Rabbit Anti Human CD80 Monoclonal Clone AOEH-3

IRBAHUCD80AOEH3C100UL each
EUR 496
Description: Rabbit Anti Human CD80 Monoclonal Clone AOEH-3

PE-Cy5 anti-human CD80

E16FHC080-025 25 tests
EUR 476.67
Description: Available in various conjugation types.

PE-Cy5 anti-human CD80

E16FHC080-100 100 tests
EUR 1083.33
Description: Available in various conjugation types.

PE-Cy7 anti-human CD80

E16FHN080-025 25 tests
EUR 520
Description: Available in various conjugation types.

PE-Cy7 anti-human CD80

E16FHN080-100 100 tests
EUR 1126.67
Description: Available in various conjugation types.

Mouse Anti-Human CD80 mAb

CM015-100ug 100ug
EUR 224.4

Mouse Anti-Human CD80 mAb

CM015-25ug 25ug
EUR 146.4

Human T- lymphocyte activation antigen CD80, CD80 ELISA KIT

ELI-06511h 96 Tests
EUR 988.8

NE Purified anti-human CD80

E16FHY080-050U 50 μg
EUR 433.33
Description: Available in various conjugation types.

NE Purified anti-human CD80

E16FHY080-500U 500 μg
EUR 1256.67
Description: Available in various conjugation types.

Anti-Hu CD80 PE

1P-287-T025 25 tests
EUR 168

Anti-Hu CD80 PE

1P-287-T100 100 tests
EUR 288

Anti-Hu CD80 APC

1A-287-T025 25 tests
EUR 168

Anti-Hu CD80 APC

1A-287-T100 100 tests
EUR 288

PE anti-rat CD80

E16FRP080-050U 50 μg
EUR 390
Description: Available in various conjugation types.

Anti-Hu CD80 FITC

1F-287-T025 25 tests
EUR 146.4

Anti-Hu CD80 FITC

1F-287-T100 100 tests
EUR 244.8

Anti-Hu CD80 PerCP

PC-287-T025 25 tests
EUR 168

Anti-Hu CD80 PerCP

PC-287-T100 100 tests
EUR 288

PE anti-mouse CD80

E16FMP080-050U 50 μg
EUR 405.33
Description: Available in various conjugation types.

PE anti-mouse CD80

E16FMP080-100U 100 μg
EUR 629.33
Description: Available in various conjugation types.

PE anti-mouse CD80

E16FMP080-200U 200 μg
EUR 1258.67
Description: Available in various conjugation types.
  • With mammalian cells, fractionation research point out that the lowered pyridine nucleotide cofactor, NADH, is accountable for most MTT discount and that is supported by research with entire cells.

 

  • MTT discount is related not solely with mitochondria, but additionally with the cytoplasm and with non-mitochondrial membranes together with the endosome/lysosome compartment and the plasma membrane.

 

  • The internet optimistic cost on tetrazolium salts like MTT and NBT seems to be the predominant issue concerned in their mobile uptake by way of the plasma membrane potential. However, second era tetrazolium dyes that kind water-soluble formazans and require an intermediate electron acceptor for discount (XTT, WST-1 and to some extent, MTS), are characterised by a internet destructive cost and are due to this fact largely cell-impermeable.

 

  • Considerable proof signifies that their discount happens on the cell floor, or on the stage of the plasma membrane by way of trans-plasma membrane electron transport. The implications of those new findings are mentioned in phrases of using tetrazolium dyes as indicators of cell metabolism and their purposes in cell biology.