Translating cell biology into therapeutic advances in Alzheimer’s disease.

Studies of the molecular foundation of Alzheimer’s illness exemplify the more and more blurred distinction between primary and utilized biomedical analysis. The 4 genes up to now implicated in familial Alzheimer’s illness have every been proven to raise mind ranges of the self-aggregating amyloid-beta protein, main step by step to profound neuronal and glial alteration, synaptic loss and dementia. Progress in understanding this cascade has helped to determine particular therapeutic targets and gives a mannequin for elucidating different neurodegenerative problems.

 

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Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative motion.

 

  • The double-stranded RNA-dependent protein kinase PKR is a vital mediator of the antiproliferative and antiviral results exerted by interferons.

 

  • Not solely is PKR an effector molecule on the mobile response to double-stranded RNA, nevertheless it additionally integrates indicators in response to Toll-like receptor activation, progress components, and numerous mobile stresses.

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280.00

Recombinant Caenorhabditis Elegans clec-159 Protein (aa 1-207)

VAng-Ly3238-1mgEcoli 1 mg (E. coli)
EUR 3514.00
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 159 (clec-159), recombination protein.

Recombinant Caenorhabditis Elegans clec-159 Protein (aa 1-207)

VAng-Ly3238-500gEcoli 500 µg (E. coli)
EUR 2511.00
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 159 (clec-159), recombination protein.

Recombinant Caenorhabditis Elegans clec-159 Protein (aa 1-207)

VAng-Ly3238-50gEcoli 50 µg (E. coli)
EUR 1714.00
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 159 (clec-159), recombination protein.

Anti-Apaf-1 (human) Monoclonal Antibody (2E12)

M00889-1 100ug
EUR 432.00
Description: Rat Monoclonal Apaf-1 (human) Antibody (2E12). Validated in ELISA, IP, IF, WB and tested in Human.

Anti-PARP-1 Antibody

A00122-1 100ul
EUR 397.00
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse.

Anti-Presenilin 1 Antibody

A00138-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat.

Anti-PAI-1 Antibody

A00637-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat.

Anti-Flk-1 Antibody

A00901-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse.

Anti-EDG-1 Antibody

A01502-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat.

Anti-ROBO-1 Antibody

A01530-1 100ug
EUR 455.00
Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Bag-1 Antibody

A02423-1 50 ul
EUR 397.00
Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat.

Anti-TUB 1 Antibody

A02917-1 100ug/vial
EUR 294.00

Anti-Dok-1 Antibody

A03039-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat.

Anti-Cerebellin 1 Antibody

A09176-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-DOC-1 Antibody

A09467-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse.

Anti-TFIIIB90-1 Antibody

A03761-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse.

Anti-Atrophin-1 Antibody

A03828-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-CNG-1 Antibody

A05494-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat.

Anti-NPDC-1 Antibody

A12846-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Periphilin 1 Antibody

A06996-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse.

Anti-Lyl-1 Antibody

A07491-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-GLI-1 Antibody

A07972-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat.

Anti-P-glycoprotein (human) Monoclonal Antibody (JSB-1)

M00049-1 125ug
EUR 586.00
Description: Mouse Monoclonal P-glycoprotein (human) Antibody (JSB-1). Validated in IF and tested in Human.

Anti-TNF Receptor 1 Antibody

A00294-1 200ug
EUR 522.00
Description: Rabbit Polyclonal TNF Receptor 1 Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat.

Anti-Galectin 1/Lgals1 Antibody

A00470-1 100ug/vial
EUR 334.00

Anti-LOX-1/OLR1 Antibody

A00760-1 100ug/vial
EUR 294.00

Anti-Syndecan-1/SDC1 Antibody

A00991-1 100ug/vial
EUR 294.00

Anti-IRAK-1/IRAK1 Antibody

A01021-1 100ug/vial
EUR 334.00

Anti-Neurexin 1/NRXN1 Antibody

A01490-1 100ug/vial
EUR 334.00

Anti-Hexokinase 1/HK1 Antibody

A01504-1 100ug/vial
EUR 334.00

Anti-Synaptotagmin 1/SYT1 Antibody

A02314-1 100ug/vial
EUR 334.00

Anti-Syntenin-1 Monoclonal Antibody

A02475-1 100ul
EUR 397.00
Description: Mouse Monoclonal Antibody for Syntenin-1 Antibody (SDCBP) detection. Tested with WB in Human, Rat, Dog, Pig.

Anti-Dsg1/Desmoglein 1 Antibody

A02655-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for Dsg1 Antibody (DSG1) detection.tested for IHC, WB in Human, Mouse, Rat.

Anti-CAF-1 p150 Antibody

A02732-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for CAF-1 p150 Antibody (CHAF1A) detection. Tested with WB in Human, Mouse.

Anti-Talin 1/TLN1 Antibody

A02859-1 100ug/vial
EUR 334.00

Anti-Islet 1/ISL1 Antibody

A02969-1 100ug/vial
EUR 334.00

Anti-Relaxin 1/RLN1 Antibody

A08367-1 100ug/vial
EUR 334.00

Anti-TCP-1 zeta Antibody

A09373-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for TCP-1 zeta Antibody (CCT6A) detection.tested for WB in Human, Mouse, Rat.

Anti-CHST8/Galnac4St 1 Antibody

A10989-1 100ul
EUR 397.00
Description: Rabbit Polyclonal CHST8/Galnac4St 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Musashi 1/Msi1 Antibody

A05052-1 100ug/vial
EUR 334.00

Anti-Pyrophosphatase 1/PPA1 Antibody

A07485-1 100ug/vial
EUR 334.00

Anti-TCP-1 eta Antibody

A08169-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for TCP-1 eta Antibody (CCT7) detection. Tested with WB in Human, Mouse, Rat.

Anti-Dynamin 1 Monoclonal Antibody

M02536-1 100ug
EUR 397.00
Description: Rabbit Monoclonal Dynamin 1 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-Esrp-1 Monoclonal Antibody

M06068-1 100uL
EUR 443.00
Description: Mouse Monoclonal Esrp-1 Antibody. Validated in WB and tested in Human.

Anti-Presenilin 1 Monoclonal Antibody

M00138-1 100ug
EUR 397.00
Description: Rabbit Monoclonal Presenilin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-DJ-1 Monoclonal Antibody

M00757-1 100ul
EUR 397.00
Description: Mouse Monoclonal DJ-1 Antibody. Validated in IHC, WB and tested in Bovine, Human.

Anti-Enolase 1 Monoclonal Antibody

M01250-1 100ul
EUR 397.00
Description: Anti-Enolase 1 Monoclonal Antibody tested in WB, IF, ICC, IHC, reactive to Human, rat, mouse, cow, pig, horse
  • In this evaluation, we offer an in depth image on how signaling downstream of PKR unfolds and what are the last word penalties for the cell destiny. PKR activation impacts each transcription and translation.

 

  • PKR phosphorylation of the alpha subunit of eukaryotic initiation issue 2 outcomes in a blockade on translation initiation. However, PKR can’t keep away from the interpretation of some mobile and viral mRNAs bearing particular options in their 5′ untranslated areas.

 

  • In addition, PKR impacts numerous transcriptional components resembling interferon regulatory issue 1, STATs, p53, activating transcription issue 3, and NF-kappaB. In specific, how PKR triggers a cascade of occasions involving IKK phosphorylation of IkappaB and NF-kappaB nuclear translocation has been intensively studied.

 

  • At the mobile and organism ranges PKR exerts antiproliferative results, and it’s a key antiviral agent. Some extent of convergence in each results is that PKR activation outcomes in apoptosis induction.

 

  • The extent and power of the antiviral motion of PKR are clearly understood by the findings that unrelated viral proteins of animal viruses have advanced to inhibit PKR motion by utilizing numerous methods. The case for the pathological penalties of the antiproliferative motion of PKR is much less understood, however therapeutic methods geared toward focusing on PKR are starting to supply promising outcomes.

 

  • Tetrazolium salts have change into among the most generally used instruments in cell biology for measuring the metabolic exercise of cells starting from mammalian to microbial origin.
anti-CD80
YF-PA10784 100 ug
EUR 403.00
Description: Rabbit polyclonal to CD80
anti- CD80 antibody
FNab01500 100µg
EUR 548.75
Description: Antibody raised against CD80
anti- CD80 antibody
FNab09813 100µg
EUR 548.75
Description: Antibody raised against CD80
Anti-CD80 Antibody
A00196-1 100ug/vial
EUR 334.00
anti-CD80 (2A2)
LF-MA30281 100 ul
EUR 486.00
Description: Mouse Monoclonal to CD80
Anti-CD80 Antibody
PA1365 100ug/vial
EUR 294.00
Anti-CD80 Antibody
PA1365-1 100ug/vial
EUR 294.00
Anti-CD80 antibody
PAab01500 100 ug
EUR 386.00
Anti-CD80 antibody
STJ118492 100 µl
EUR 277.00
Anti-CD80 antibody
STJ16100188 100 µg
EUR 403.00
Anti-CD80 antibody
STJ16100189 100 µg
EUR 524.00
Anti-CD80 antibody
STJ16101125 100 µg
EUR 354.00
Anti-CD80 antibody
STJ170002 100 µg
EUR 341.00
Description: The CD80 antigen (B7, BB1) recognizes a 60 kDa transmembrane glycoprotein, member of the immunoglobulin family. This molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells activated monocytes, and constitutively on dendritic cells. CD80 binding provides costimulatory signals for T cell activation.
Anti-CD80 Antibody
STJ500483 100 µg
EUR 476.00
Anti-CD80 antibody
STJ72065 100 µg
EUR 359.00
Anti-CD80 antibody
STJ97938 100 µl
EUR 234.00
Description: Mouse monoclonal to CD80.
Anti-CD80 antibody
STJ98977 200 µl
EUR 197.00
Description: Rabbit polyclonal to CD80.
Anti-CD80 (1G1)
YF-MA12322 100 ug
EUR 363.00
Description: Mouse monoclonal to CD80
Anti-CD80 (3E10)
YF-MA12323 200 ul
EUR 363.00
Description: Mouse monoclonal to CD80
Anti-CD80 (4A4)
YF-MA12324 200 ul
EUR 363.00
Description: Mouse monoclonal to CD80
Anti-CD80 (3D7)
YF-MA12325 100 ug
EUR 363.00
Description: Mouse monoclonal to CD80
Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349.00
Mouse Anti-Human CD80 mAb
CM015-100ug 100ug
EUR 187.00
Mouse Anti-Human CD80 mAb
CM015-25ug 25ug
EUR 122.00
Anti-Hu CD80 Purified
11-287-C025 0.025 mg
EUR 104.00
Anti-Hu CD80 Purified
11-287-C100 0.1 mg
EUR 167.00
Anti-Hu CD80 FITC
1F-287-T025 25 tests
EUR 122.00
Anti-Hu CD80 FITC
1F-287-T100 100 tests
EUR 204.00
Anti-Hu CD80 PE
1P-287-T025 25 tests
EUR 140.00
Anti-Hu CD80 PE
1P-287-T100 100 tests
EUR 240.00
Anti-Hu CD80 APC
1A-287-T025 25 tests
EUR 140.00
Anti-Hu CD80 APC
1A-287-T100 100 tests
EUR 240.00
Anti-Ms CD80 Purified
11-627-C100 0.1 mg
EUR 113.00
Anti-Hu CD80 PerCP
PC-287-T025 25 tests
EUR 140.00
Anti-Hu CD80 PerCP
PC-287-T100 100 tests
EUR 240.00
Anti-CD80 Antibody BIOTIN
STJ500484 100 µg
EUR 586.00
Anti-CD80 Antibody FITC
STJ500485 100 µg
EUR 586.00
Mouse Anti-Human CD80 mAbConjugated Antibody
CCM015 100ul
EUR 397.00
CD80
80A-100T 100 test
EUR 375.00
CD80
80F-100T 100 test
EUR 310.00
CD80
80PE-100T 100 test
EUR 635.00
CD80
MO80A(V100) 100 ug
EUR 50.00
CD80
MO80A(V25) 25 ug
EUR 50.00
  • With mammalian cells, fractionation research point out that the lowered pyridine nucleotide cofactor, NADH, is accountable for most MTT discount and that is supported by research with entire cells.

 

  • MTT discount is related not solely with mitochondria, but additionally with the cytoplasm and with non-mitochondrial membranes together with the endosome/lysosome compartment and the plasma membrane.

 

  • The internet optimistic cost on tetrazolium salts like MTT and NBT seems to be the predominant issue concerned in their mobile uptake by way of the plasma membrane potential. However, second era tetrazolium dyes that kind water-soluble formazans and require an intermediate electron acceptor for discount (XTT, WST-1 and to some extent, MTS), are characterised by a internet destructive cost and are due to this fact largely cell-impermeable.

 

  • Considerable proof signifies that their discount happens on the cell floor, or on the stage of the plasma membrane by way of trans-plasma membrane electron transport. The implications of those new findings are mentioned in phrases of using tetrazolium dyes as indicators of cell metabolism and their purposes in cell biology.