Studies of the molecular foundation of Alzheimer’s illness exemplify the more and more blurred distinction between primary and utilized biomedical analysis. The 4 genes up to now implicated in familial Alzheimer’s illness have every been proven to raise mind ranges of the self-aggregating amyloid-beta protein, main step by step to profound neuronal and glial alteration, synaptic loss and dementia. Progress in understanding this cascade has helped to determine particular therapeutic targets and gives a mannequin for elucidating different neurodegenerative problems.

Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative motion.
- The double-stranded RNA-dependent protein kinase PKR is a vital mediator of the antiproliferative and antiviral results exerted by interferons.
- Not solely is PKR an effector molecule on the mobile response to double-stranded RNA, nevertheless it additionally integrates indicators in response to Toll-like receptor activation, progress components, and numerous mobile stresses.
Recombinant Caenorhabditis Elegans clec-159 Protein (aa 1-207) |
VAng-Ly3238-50gEcoli |
Creative Biolabs |
50 µg (E. coli) |
EUR 1714 |
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 159 (clec-159), recombination protein. |
Anti-Apaf-1 (human) Monoclonal Antibody (2E12) |
M00889-1 |
BosterBio |
100ug |
EUR 432 |
Description: Rat Monoclonal Apaf-1 (human) Antibody (2E12). Validated in ELISA, IP, IF, WB and tested in Human. |
Anti-PARP-1 Antibody |
A00122-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse. |
Anti-Presenilin 1 Antibody |
A00138-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat. |
Anti-CNG-1 Antibody |
A05494-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-Periphilin 1 Antibody |
A06996-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse. |
Anti-Lyl-1 Antibody |
A07491-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat. |
Anti-GLI-1 Antibody |
A07972-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-Cerebellin 1 Antibody |
A09176-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-DOC-1 Antibody |
A09467-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse. |
Anti-PAI-1 Antibody |
A00637-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat. |
Anti-Flk-1 Antibody |
A00901-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse. |
Anti-EDG-1 Antibody |
A01502-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat. |
Anti-ROBO-1 Antibody |
A01530-1 |
BosterBio |
100ug |
EUR 455 |
Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat. |
Anti-NPDC-1 Antibody |
A12846-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-Bag-1 Antibody |
A02423-1 |
BosterBio |
50 ul |
EUR 397 |
Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat. |
Anti-TUB 1 Antibody |
A02917-1 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Dok-1 Antibody |
A03039-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat. |
Anti-TFIIIB90-1 Antibody |
A03761-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse. |
Anti-Atrophin-1 Antibody |
A03828-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat. |
Anti-P-glycoprotein (human) Monoclonal Antibody (JSB-1) |
M00049-1 |
BosterBio |
125ug |
EUR 586 |
Description: Mouse Monoclonal P-glycoprotein (human) Antibody (JSB-1). Validated in IF and tested in Human. |
Recombinant Caenorhabditis Elegans clec-161 Protein (aa 21-862) |
VAng-Ly3239-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 161 (clec-161), partial, recombination protein. |
Recombinant Caenorhabditis Elegans clec-162 Protein (aa 18-313) |
VAng-Ly3240-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 4078 |
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 162 (clec-162), recombination protein. |
Recombinant Caenorhabditis Elegans clec-162 Protein (aa 18-313) |
VAng-Ly3240-500gEcoli |
Creative Biolabs |
500 µg (E. coli) |
EUR 2895 |
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 162 (clec-162), recombination protein. |
Recombinant Caenorhabditis Elegans clec-162 Protein (aa 18-313) |
VAng-Ly3240-50gEcoli |
Creative Biolabs |
50 µg (E. coli) |
EUR 1975 |
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 162 (clec-162), recombination protein. |
Recombinant Caenorhabditis Elegans clec-91 Protein (aa 22-225) |
VAng-Ly3241-1mgEcoli |
Creative Biolabs |
1 mg (E. coli) |
EUR 3500 |
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 91 (clec-91), recombination protein. |
Recombinant Caenorhabditis Elegans clec-91 Protein (aa 22-225) |
VAng-Ly3241-500gEcoli |
Creative Biolabs |
500 µg (E. coli) |
EUR 2498 |
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 91 (clec-91), recombination protein. |
Recombinant Caenorhabditis Elegans clec-91 Protein (aa 22-225) |
VAng-Ly3241-50gEcoli |
Creative Biolabs |
50 µg (E. coli) |
EUR 1700 |
Description: Caenorhabditis Elegans C-type lectin domain-containing protein 91 (clec-91), recombination protein. |
Anti-Presenilin 1 Monoclonal Antibody |
M00138-1 |
BosterBio |
100ug |
EUR 397 |
Description: Rabbit Monoclonal Presenilin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
Anti-Galectin 1 Monoclonal Antibody |
M00470-1 |
BosterBio |
100ug |
EUR 397 |
Description: Rabbit Monoclonal Galectin 1 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat. |
Anti-DJ-1 Monoclonal Antibody |
M00757-1 |
BosterBio |
100ul |
EUR 397 |
Description: Mouse Monoclonal DJ-1 Antibody. Validated in IHC, WB and tested in Bovine, Human. |
Anti-Enolase 1 Monoclonal Antibody |
M01250-1 |
BosterBio |
100ul |
EUR 397 |
Description: Anti-Enolase 1 Monoclonal Antibody tested in WB, IF, ICC, IHC, reactive to Human, rat, mouse, cow, pig, horse |
Anti-Dynamin 1 Monoclonal Antibody |
M02536-1 |
BosterBio |
100ug |
EUR 397 |
Description: Rabbit Monoclonal Dynamin 1 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
Anti-Esrp-1 Monoclonal Antibody |
M06068-1 |
BosterBio |
100uL |
EUR 443 |
Description: Mouse Monoclonal Esrp-1 Antibody. Validated in WB and tested in Human. |
Anti-Angiopoietin 1/ANGPT1 Antibody |
PA1333-1 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Galectin 1/LGALS1 Antibody |
PB9240-1 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-TNF Receptor 1 Antibody |
A00294-1 |
BosterBio |
200ug |
EUR 522 |
Description: Rabbit Polyclonal TNF Receptor 1 Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat. |
Anti-CHST8/Galnac4St 1 Antibody |
A10989-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal CHST8/Galnac4St 1 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
Anti-Pyrophosphatase 1/PPA1 Antibody |
A07485-1 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-TCP-1 eta Antibody |
A08169-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for TCP-1 eta Antibody (CCT7) detection. Tested with WB in Human, Mouse, Rat. |
Anti-Relaxin 1/RLN1 Antibody |
A08367-1 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-TCP-1 zeta Antibody |
A09373-1 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for TCP-1 zeta Antibody (CCT6A) detection.tested for WB in Human, Mouse, Rat. |
Anti-Galectin 1/Lgals1 Antibody |
A00470-1 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-LOX-1/OLR1 Antibody |
A00760-1 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Syndecan-1/SDC1 Antibody |
A00991-1 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-IRAK-1/IRAK1 Antibody |
A01021-1 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Neurexin 1/NRXN1 Antibody |
A01490-1 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Hexokinase 1/HK1 Antibody |
A01504-1 |
BosterBio |
100ug/vial |
EUR 334 |
- In this evaluation, we offer an in depth image on how signaling downstream of PKR unfolds and what are the last word penalties for the cell destiny. PKR activation impacts each transcription and translation.
- PKR phosphorylation of the alpha subunit of eukaryotic initiation issue 2 outcomes in a blockade on translation initiation. However, PKR can’t keep away from the interpretation of some mobile and viral mRNAs bearing particular options in their 5′ untranslated areas.
- In addition, PKR impacts numerous transcriptional components resembling interferon regulatory issue 1, STATs, p53, activating transcription issue 3, and NF-kappaB. In specific, how PKR triggers a cascade of occasions involving IKK phosphorylation of IkappaB and NF-kappaB nuclear translocation has been intensively studied.
- At the mobile and organism ranges PKR exerts antiproliferative results, and it’s a key antiviral agent. Some extent of convergence in each results is that PKR activation outcomes in apoptosis induction.
- The extent and power of the antiviral motion of PKR are clearly understood by the findings that unrelated viral proteins of animal viruses have advanced to inhibit PKR motion by utilizing numerous methods. The case for the pathological penalties of the antiproliferative motion of PKR is much less understood, however therapeutic methods geared toward focusing on PKR are starting to supply promising outcomes.
- Tetrazolium salts have change into among the most generally used instruments in cell biology for measuring the metabolic exercise of cells starting from mammalian to microbial origin.
Anti-CD80 Antibody |
PA1365-1 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-CD80 Antibody |
A00196-1 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-CD80 antibody |
STJ98977 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to CD80. |
Anti-CD80 antibody |
STJ97938 |
St John's Laboratory |
100 µl |
EUR 234 |
Description: Mouse monoclonal to CD80. |
Anti-CD80 antibody |
STJ170002 |
St John's Laboratory |
100 µg |
EUR 341 |
Description: The CD80 antigen (B7, BB1) recognizes a 60 kDa transmembrane glycoprotein, member of the immunoglobulin family. This molecule shares with CD86 the capability to be the ligand for two structurally similar molecules expressed on T lymphocytes, CD28 and CD152 (CTLA-4). CD80 antigen is expressed on in vitro activated B lymphocytes. It is not expressed on the majority of resting B cells from peripheral blood but identifies a subpopulation of B cells that has been previously activated. The antigen is also expressed by HTLV-1 transformed T cells activated monocytes, and constitutively on dendritic cells. CD80 binding provides costimulatory signals for T cell activation. |
anti- CD80 antibody |
FNab09813 |
FN Test |
100µg |
EUR 548.75 |
Description: Antibody raised against CD80 |
anti- CD80 antibody |
FNab01500 |
FN Test |
100µg |
EUR 548.75 |
Description: Antibody raised against CD80 |
anti-CD80 (2A2) |
LF-MA30281 |
Abfrontier |
100 ul |
EUR 486 |
Description: Mouse Monoclonal to CD80 |
Anti-CD80 (1G1) |
YF-MA12322 |
Abfrontier |
100 ug |
EUR 363 |
Description: Mouse monoclonal to CD80 |
Anti-CD80 (3E10) |
YF-MA12323 |
Abfrontier |
200 ul |
EUR 363 |
Description: Mouse monoclonal to CD80 |
Anti-CD80 (4A4) |
YF-MA12324 |
Abfrontier |
200 ul |
EUR 363 |
Description: Mouse monoclonal to CD80 |
Anti-CD80 (3D7) |
YF-MA12325 |
Abfrontier |
100 ug |
EUR 363 |
Description: Mouse monoclonal to CD80 |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
Mouse Anti-Human CD80 mAb |
CM015-100ug |
SAB |
100ug |
EUR 187 |
Mouse Anti-Human CD80 mAb |
CM015-25ug |
SAB |
25ug |
EUR 122 |
Anti-Hu CD80 PerCP |
PC-287-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-Hu CD80 PerCP |
PC-287-T100 |
ExBio |
100 tests |
EUR 240 |
Anti-Hu CD80 APC |
1A-287-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-Hu CD80 APC |
1A-287-T100 |
ExBio |
100 tests |
EUR 240 |
Anti-Hu CD80 FITC |
1F-287-T025 |
ExBio |
25 tests |
EUR 122 |
Anti-Hu CD80 FITC |
1F-287-T100 |
ExBio |
100 tests |
EUR 204 |
Anti-Hu CD80 PE |
1P-287-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-Hu CD80 PE |
1P-287-T100 |
ExBio |
100 tests |
EUR 240 |
Anti-Hu CD80 Purified |
11-287-C025 |
ExBio |
0.025 mg |
EUR 104 |
Anti-Hu CD80 Purified |
11-287-C100 |
ExBio |
0.1 mg |
EUR 167 |
Anti-Ms CD80 Purified |
11-627-C100 |
ExBio |
0.1 mg |
EUR 113 |
Mouse Anti-Human CD80 mAbConjugated Antibody |
CCM015 |
SAB |
100ul |
EUR 397 |
- With mammalian cells, fractionation research point out that the lowered pyridine nucleotide cofactor, NADH, is accountable for most MTT discount and that is supported by research with entire cells.
- MTT discount is related not solely with mitochondria, but additionally with the cytoplasm and with non-mitochondrial membranes together with the endosome/lysosome compartment and the plasma membrane.
- The internet optimistic cost on tetrazolium salts like MTT and NBT seems to be the predominant issue concerned in their mobile uptake by way of the plasma membrane potential. However, second era tetrazolium dyes that kind water-soluble formazans and require an intermediate electron acceptor for discount (XTT, WST-1 and to some extent, MTS), are characterised by a internet destructive cost and are due to this fact largely cell-impermeable.
- Considerable proof signifies that their discount happens on the cell floor, or on the stage of the plasma membrane by way of trans-plasma membrane electron transport. The implications of those new findings are mentioned in phrases of using tetrazolium dyes as indicators of cell metabolism and their purposes in cell biology.