Studies of the molecular foundation of Alzheimer’s illness exemplify the more and more blurred distinction between primary and utilized biomedical analysis. The 4 genes up to now implicated in familial Alzheimer’s illness have every been proven to raise mind ranges of the self-aggregating amyloid-beta protein, main step by step to profound neuronal and glial alteration, synaptic loss and dementia. Progress in understanding this cascade has helped to determine particular therapeutic targets and gives a mannequin for elucidating different neurodegenerative problems.
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative motion.
- The double-stranded RNA-dependent protein kinase PKR is a vital mediator of the antiproliferative and antiviral results exerted by interferons.
- Not solely is PKR an effector molecule on the mobile response to double-stranded RNA, nevertheless it additionally integrates indicators in response to Toll-like receptor activation, progress components, and numerous mobile stresses.
 Human CLEC-1 HEK293 Overexpression Lysate |
|
MBS8114905-03mg |
MyBiosource |
0.3mg |
EUR 280 |
Human CLEC-1 HEK293 Overexpression Lysate |
|
MBS8114905-5x03mg |
MyBiosource |
5x0.3mg |
EUR 1205 |
) Recombinant Human CLEC1A/CLEC-1 Protein (Fc Tag) |
|
PKSH030889-50ug |
Elabscience Biotech |
50ug |
EUR 670 |
|
Description: Human |
) Mouse Monoclonal anti-human CLEC-2 (CLEC1B) |
|
hAP-0188 |
Angio Proteomie |
100ug |
EUR 250 |
) Sheep Polyclonal anti-Human CLEC-2 (CLEC1B) |
|
hAP-5775 |
Angio Proteomie |
50ug |
EUR 400 |
) CLEC-1 Protein, Human, Recombinant (hFc Tag) |
|
MBS8121103-005mg |
MyBiosource |
0.05mg |
EUR 340 |
CLEC-1 Protein, Human, Recombinant (hFc Tag) |
|
MBS8121103-5x005mg |
MyBiosource |
5x0.05mg |
EUR 1380 |
) Mouse Monoclonal anti-human Tetranectin (CLEC-3B) |
|
hAP-0639 |
Angio Proteomie |
100ug |
EUR 250 |
) Sheep Polyclonal anti-Human Tetranectin (CLEC-3B) |
|
hAP-5777 |
Angio Proteomie |
50ug |
EUR 400 |
 Human CLEC-2 HEK293 Overexpression Lysate |
|
MBS8114270-03mg |
MyBiosource |
0.3mg |
EUR 280 |
Human CLEC-2 HEK293 Overexpression Lysate |
|
MBS8114270-5x03mg |
MyBiosource |
5x0.3mg |
EUR 1205 |
) CLEC-2 Protein, Human, Recombinant (His Tag) |
|
MBS8120607-01mg |
MyBiosource |
0.1mg |
EUR 450 |
CLEC-2 Protein, Human, Recombinant (His Tag) |
|
MBS8120607-1mg |
MyBiosource |
1mg |
EUR 2530 |
CLEC-2 Protein, Human, Recombinant (His Tag) |
|
MBS8120607-5x1mg |
MyBiosource |
5x1mg |
EUR 11240 |
 ELISA Kit) Human C-type lectin-like receptor 1(CLEC-1) ELISA Kit |
|
YLA4238HU-48T |
Shanghai YL Biotech |
48T |
Ask for price |
Human C-type lectin-like receptor 1(CLEC-1) ELISA Kit |
|
YLA4238HU-96T |
Shanghai YL Biotech |
96T |
Ask for price |
) Human CLEC-2 / CLEC1B Protein, His Tag (MALS verified) |
|
CL2-H5247 |
ACROBIOSYSTEMS |
100ug |
EUR 2749.9 |
|
Description: Human CLEC-2, His Tag (CL2-H5247) is expressed from human 293 cells (HEK293). It contains AA Ser 55 - Pro 229 (Accession # Q9P126-1). |
) Human CLEC-2 / CLEC1B Protein, Fc Tag (MALS & SPR verified) |
|
CL2-H5254 |
ACROBIOSYSTEMS |
100ug |
EUR 2493.1 |
|
Description: Human CLEC-2, Fc Tag (CL2-H5254) is expressed from human 293 cells (HEK293). It contains AA Ser 55 - Pro 229 (Accession # Q9P126-1). |
 Rabbit anti-Caenorhabditis elegans clec-141 Polyclonal Antibody |
|
MBS7146187-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Rabbit anti-Caenorhabditis elegans clec-160 Polyclonal Antibody |
|
MBS7155259-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Rabbit anti-Caenorhabditis elegans clec-161 Polyclonal Antibody |
|
MBS7158228-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Rabbit anti-Caenorhabditis elegans clec-162 Polyclonal Antibody |
|
MBS7159039-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Rabbit anti-Caenorhabditis elegans clec-180 Polyclonal Antibody |
|
MBS7190225-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Rabbit anti-Caenorhabditis elegans clec-158 Polyclonal Antibody |
|
MBS7192271-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Rabbit anti-Caenorhabditis elegans clec-87 Polyclonal Antibody |
|
MBS9015280-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Rabbit anti-Caenorhabditis elegans clec-91 Polyclonal Antibody |
|
MBS9005737-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Rabbit anti-Caenorhabditis elegans clec-88 Polyclonal Antibody |
|
MBS9001663-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 CLEC 4E Polyclonal Antibody |
|
MBS9238603-01mL |
MyBiosource |
0.1mL |
EUR 415 |
CLEC 4E Polyclonal Antibody |
|
MBS9238603-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1841 |
 Antibody) CLEC1B/CLEC-2 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody |
|
MBS2402184-005mL |
MyBiosource |
0.05mL |
EUR 615 |
CLEC1B/CLEC-2 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody |
|
MBS2402184-5x005mL |
MyBiosource |
5x0.05mL |
EUR 2605 |
 Rat CLEC-1 HEK293 Overexpression Lysate |
|
MBS8117466-03mg |
MyBiosource |
0.3mg |
EUR 280 |
Rat CLEC-1 HEK293 Overexpression Lysate |
|
MBS8117466-5x03mg |
MyBiosource |
5x0.3mg |
EUR 1205 |
 Mouse CLEC-1 HEK293 Overexpression Lysate |
|
MBS8116525-03mg |
MyBiosource |
0.3mg |
EUR 280 |
Mouse CLEC-1 HEK293 Overexpression Lysate |
|
MBS8116525-5x03mg |
MyBiosource |
5x0.3mg |
EUR 1205 |
 Anti-CLEC-1 Antibody |
|
MBS8306312-005mL |
MyBiosource |
0.05mL |
EUR 210 |
Anti-CLEC-1 Antibody |
|
MBS8306312-01mL |
MyBiosource |
0.1mL |
EUR 255 |
Anti-CLEC-1 Antibody |
|
MBS8306312-02mL |
MyBiosource |
0.2mL |
EUR 335 |
Anti-CLEC-1 Antibody |
|
MBS8306312-5x02mL |
MyBiosource |
5x0.2mL |
EUR 1420 |
 Recombinant AICL/CLEC-2B |
|
MBS201063-001mg |
MyBiosource |
0.01mg |
EUR 340 |
Recombinant AICL/CLEC-2B |
|
MBS201063-005mg |
MyBiosource |
0.05mg |
EUR 985 |
Recombinant AICL/CLEC-2B |
|
MBS201063-5x005mg |
MyBiosource |
5x0.05mg |
EUR 4180 |
 CLEC 4E Antibody HRP Conjugated |
|
MBS9461896-01mL |
MyBiosource |
0.1mL |
EUR 595 |
CLEC 4E Antibody HRP Conjugated |
|
MBS9461896-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2525 |
- In this evaluation, we offer an in depth image on how signaling downstream of PKR unfolds and what are the last word penalties for the cell destiny. PKR activation impacts each transcription and translation.
- PKR phosphorylation of the alpha subunit of eukaryotic initiation issue 2 outcomes in a blockade on translation initiation. However, PKR can’t keep away from the interpretation of some mobile and viral mRNAs bearing particular options in their 5′ untranslated areas.
- In addition, PKR impacts numerous transcriptional components resembling interferon regulatory issue 1, STATs, p53, activating transcription issue 3, and NF-kappaB. In specific, how PKR triggers a cascade of occasions involving IKK phosphorylation of IkappaB and NF-kappaB nuclear translocation has been intensively studied.
- At the mobile and organism ranges PKR exerts antiproliferative results, and it’s a key antiviral agent. Some extent of convergence in each results is that PKR activation outcomes in apoptosis induction.
- The extent and power of the antiviral motion of PKR are clearly understood by the findings that unrelated viral proteins of animal viruses have advanced to inhibit PKR motion by utilizing numerous methods. The case for the pathological penalties of the antiproliferative motion of PKR is much less understood, however therapeutic methods geared toward focusing on PKR are starting to supply promising outcomes.
- Tetrazolium salts have change into among the most generally used instruments in cell biology for measuring the metabolic exercise of cells starting from mammalian to microbial origin.
 MOUSE ANTI HUMAN CD80:FITC |
|
MBS210835-01mg |
MyBiosource |
0.1mg |
EUR 435 |
MOUSE ANTI HUMAN CD80:FITC |
|
MBS210835-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1785 |
 MOUSE ANTI HUMAN CD80:Preservative Free |
|
MBS210200-1mg |
MyBiosource |
1mg |
EUR 1120 |
MOUSE ANTI HUMAN CD80:Preservative Free |
|
MBS210200-5x1mg |
MyBiosource |
5x1mg |
EUR 4875 |
) Human T-lymphocyte activation antigen CD80 (CD80) |
|
1-CSB-CF1054HU |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
|
|
|
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80) expressed in in vitro E.coli expression system |
Human T-lymphocyte activation antigen CD80 (CD80) |
|
1-CSB-MP004959HU1 |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
|
|
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80),partial expressed in Mammalian cell |
 PE anti-human CD80 |
|
E16FHP080-025 |
EnoGene |
25 tests |
EUR 293.67 |
|
Description: Available in various conjugation types. |
PE anti-human CD80 |
|
E16FHP080-050 |
EnoGene |
50 tests |
EUR 419.33 |
|
Description: Available in various conjugation types. |
PE anti-human CD80 |
|
E16FHP080-100 |
EnoGene |
100 Tests |
EUR 629 |
|
Description: Available in various conjugation types. |
PE anti-human CD80 |
|
MBS9459630-25Tests |
MyBiosource |
25Tests |
EUR 230 |
PE anti-human CD80 |
|
MBS9459630-50Tests |
MyBiosource |
50Tests |
EUR 290 |
PE anti-human CD80 |
|
MBS9459630-5x50Tests |
MyBiosource |
5x50Tests |
EUR 1160 |
 Anti-Human CD80 Antibody |
|
101-M315 |
ReliaTech |
100 µg |
EUR 399 |
|
Description: B7-1(CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily. |
 APC anti-human CD80 |
|
E16FHA080-025 |
EnoGene |
25 tests |
EUR 411.67 |
|
Description: Available in various conjugation types. |
APC anti-human CD80 |
|
E16FHA080-100 |
EnoGene |
100 tests |
EUR 975 |
|
Description: Available in various conjugation types. |
 FITC anti-human CD80 |
|
E16FHF080-025 |
EnoGene |
25 tests |
EUR 222.33 |
|
Description: Available in various conjugation types. |
FITC anti-human CD80 |
|
E16FHF080-050 |
EnoGene |
50 tests |
EUR 317.67 |
|
Description: Available in various conjugation types. |
FITC anti-human CD80 |
|
E16FHF080-100 |
EnoGene |
100 Tests |
EUR 496 |
|
Description: Available in various conjugation types. |
FITC anti-human CD80 |
|
MBS9459552-25Tests |
MyBiosource |
25Tests |
EUR 230 |
FITC anti-human CD80 |
|
MBS9459552-50Tests |
MyBiosource |
50Tests |
EUR 290 |
FITC anti-human CD80 |
|
MBS9459552-5x50Tests |
MyBiosource |
5x50Tests |
EUR 1160 |
 Biotin anti-human CD80 |
|
E16FHB080-100U |
EnoGene |
100 μg |
EUR 693.33 |
|
Description: Available in various conjugation types. |
 Purified anti-human CD80 |
|
E16FHU080-100U |
EnoGene |
100 μg |
EUR 190.67 |
|
Description: Available in various conjugation types. |
Purified anti-human CD80 |
|
E16FHU080-500U |
EnoGene |
500 μg |
EUR 572 |
|
Description: Available in various conjugation types. |
 Mouse anti Human CD80/B7-1 Monoclonal Antibody |
|
MBS2543446-006mL |
MyBiosource |
0.06mL |
EUR 250 |
Mouse anti Human CD80/B7-1 Monoclonal Antibody |
|
MBS2543446-012mL |
MyBiosource |
0.12mL |
EUR 370 |
Mouse anti Human CD80/B7-1 Monoclonal Antibody |
|
MBS2543446-02mL |
MyBiosource |
0.2mL |
EUR 550 |
 Protein) Human T-Lymphocyte Activation Antigen CD80 (CD80) Protein |
|
abx694244-10nmol |
Abbexa |
10 nmol |
EUR 600 |
Human T-Lymphocyte Activation Antigen CD80 (CD80) Protein |
|
abx694244-5nmol |
Abbexa |
5 nmol |
EUR 400 |
 Rabbit Anti Human CD80 Monoclonal Clone AOEH-3 |
|
IRBAHUCD80AOEH3C100UL |
Innovative research |
each |
EUR 496 |
|
Description: Rabbit Anti Human CD80 Monoclonal Clone AOEH-3 |
) Recombinant Human T-lymphocyte activation antigen CD80(CD80) |
|
AP78203 |
SAB |
each |
Ask for price |
) Recombinant Human T-lymphocyte activation antigen CD80 (CD80) |
|
CSB-CF1054HU |
Cusabio |
371 mg |
Ask for price |
) Recombinant Human T-Lymphocyte Activation Antigen CD80 (CD80) |
|
MBS7115355-002mg |
MyBiosource |
0.02mg |
EUR 1545 |
Recombinant Human T-Lymphocyte Activation Antigen CD80 (CD80) |
|
MBS7115355-01mg |
MyBiosource |
0.1mg |
EUR 2505 |
Recombinant Human T-Lymphocyte Activation Antigen CD80 (CD80) |
|
MBS7115355-5x01mg |
MyBiosource |
5x0.1mg |
EUR 11235 |
Recombinant Human T-lymphocyte activation antigen CD80 (CD80) |
|
MBS962050-INQUIRE |
MyBiosource |
INQUIRE |
Ask for price |
 Human CD80/ T-lymphocyte activation antigen CD80 ELISA Kit |
|
E0441Hu |
Sunlong |
1 Kit |
EUR 515 |
|
Description: CD28LG,CD28LG1,LAB7,Activation B7-1 antigen,BB1,CTLA-4 counter-receptor B7.1,B7,CD80 |
- With mammalian cells, fractionation research point out that the lowered pyridine nucleotide cofactor, NADH, is accountable for most MTT discount and that is supported by research with entire cells.
- MTT discount is related not solely with mitochondria, but additionally with the cytoplasm and with non-mitochondrial membranes together with the endosome/lysosome compartment and the plasma membrane.
- The internet optimistic cost on tetrazolium salts like MTT and NBT seems to be the predominant issue concerned in their mobile uptake by way of the plasma membrane potential. However, second era tetrazolium dyes that kind water-soluble formazans and require an intermediate electron acceptor for discount (XTT, WST-1 and to some extent, MTS), are characterised by a internet destructive cost and are due to this fact largely cell-impermeable.
- Considerable proof signifies that their discount happens on the cell floor, or on the stage of the plasma membrane by way of trans-plasma membrane electron transport. The implications of those new findings are mentioned in phrases of using tetrazolium dyes as indicators of cell metabolism and their purposes in cell biology.
