Biochemistry and molecular cell biology of diabetic complications.

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Diabetes-specific microvascular illness is a number one trigger of blindness, renal failure and nerve injury, and diabetes-accelerated atherosclerosis results in elevated threat of myocardial infarction, stroke and limb amputation. Four fundamental molecular mechanisms have been implicated in glucose-mediated vascular injury. All appear to replicate a single hyperglycaemia-induced course of of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm offers a brand new conceptual framework for future analysis and drug discovery.

  • Cell proliferation requires vitamins, vitality, and biosynthetic exercise to duplicate all macromolecular elements throughout every passage by the cell cycle.
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  • It is subsequently not shocking that metabolic actions in proliferating cells are basically totally different from these in nonproliferating cells.

 

  • This evaluation examines the concept a number of core fluxes, together with cardio glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, type a stereotyped platform supporting proliferation of various cell sorts. We additionally think about regulation of these fluxes by mobile mediators of sign transduction and gene expression, together with the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible issue 1 (HIF-1), and Myc, throughout physiologic cell proliferation and tumorigenesis.

 

  • Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, by its interplay with these receptors, participates within the transport of ldl cholesterol and different lipids amongst numerous cells of the physique.

Denitrification is a definite means of vitality conservation, making use of N oxides as terminal electron acceptors for mobile bioenergetics underneath anaerobic, microaerophilic, and sometimes cardio situations. The course of is a vital department of the worldwide N cycle, reversing dinitrogen fixation, and is related to chemolithotrophic, phototrophic, diazotrophic, or organotrophic metabolism however usually not with obligately anaerobic life.

Discovered greater than a century in the past and believed to be solely a bacterial trait, denitrification has now been present in halophilic and hyperthermophilic archaea and within the mitochondria of fungi, elevating evolutionarily intriguing vistas. Important advances within the biochemical characterization of denitrification and the underlying genetics have been achieved with Pseudomonas stutzeri, Pseudomonas aeruginosa, Paracoccus denitrificans, Ralstonia eutropha, and Rhodobacter sphaeroides. Pseudomonads symbolize one of the biggest assemblies of the denitrifying micro organism inside a single genus, favoring their use as mannequin organisms.

 

HBV Seroconversion Panel Donor# 65556 (6 X 1 mL)

HBV11002 6 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 65584 (8 X 1 mL)

HBV11003 8 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 65732 (8 X 1 mL)

HBV11004 8 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 65777 (14 X 1 mL)

HBV11005 14 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 66201 (17 X 1 mL)

HBV11006 17 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 66537 (14 X 1 mL)

HBV11007 14 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 67303 (18 X 1 mL)

HBV11008 18 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 67449 (23 X 1 mL)

HBV11009 23 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 67457 (18 X 1 mL)

HBV11010 18 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 67694 (14 X 1 mL)

HBV11011 14 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 67773 (6 X 1 mL)

HBV11012 6 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 67962 (35 X 1 mL)

HBV11013 35 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 68029 (12 X 1 mL)

HBV11014 12 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 68105 (14 X 1 mL)

HBV11015 14 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 68541 (10 X 1 mL)

HBV11016 10 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 68739 (14 X 1 mL)

HBV11017 14 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 70793 (14 X 1 mL)

HBV11024 14 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 70970 (16 X 1 mL)

HBV11026 16 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 71415 (13 X 1 mL)

HBV11027 13 X 1 mL
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HBV Seroconversion Panel Donor# 71840 (10 X 1 mL)

HBV11028 10 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 69751 (13 X 1 mL)

HBV11029 13 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 70292 (15 X 1 mL)

HBV11031 15 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 72439 (13 X 1 mL)

HBV11052 13 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 72474 (11 X 1 mL)

HBV11056 11 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 71612 (8 X 1 mL)

HBV11058 8 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 72324 (9 X 1 mL)

HBV11059 9 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 71922 (11 X 1 mL)

HBV11062 11 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 71782 (9 X 1 mL)

HBV11064 9 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 73299 (15 X 1 mL)

HBV11069 15 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 61248 (5 X 1 mL)

HBV6271 5 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 61291 (25 X 1 mL)

HBV6272 25 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 61042 (6 X 1 mL)

HBV6273 6 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 61799 (7 X 1 mL)

HBV6274 7 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 61066 (7 X 1 mL)

HBV6275 7 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 60409 (8 X 1 mL)

HBV6276 8 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 63291 (11 X 1 mL)

HBV6277 11 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 63426 (10 X 1 mL)

HBV6278 10 X 1 mL
EUR 1030.94
Description: Please contact Gentaur in order to receive the datasheet of the product.

HBV Seroconversion Panel Donor# 63701 (7 X 1 mL)

HBV6279 7 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 61832 (5 X 1 mL)

HBV6280 5 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 62433 (12 X 1 mL)

HBV6281 12 X 1 mL
EUR 1937

HBV Seroconversion Panel Donor# 62675 (14 X 1 mL)

HBV6282 14 X 1 mL
EUR 953

HBV Seroconversion Panel Donor# 62825 (11 X 1 mL)

HBV6283 11 X 1 mL
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HBV Seroconversion Panel Donor# 62347 (19 X 1 mL)

HBV6284 19 X 1 mL
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HBV Seroconversion Panel Donor# 62967 (16 X 1 mL)

HBV6285 16 X 1 mL
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HBV Seroconversion Panel Donor# 63133 (9 X 1 mL)

HBV6286 9 X 1 mL
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HBV6287 11 X 1 mL
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HBV Seroconversion Panel Donor# 63568 (9 X 1 mL)

HBV6288 9 X 1 mL
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HBV6289 10 X 1 mL
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HBV6290 12 X 1 mL
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HBV6291 8 X 1 mL
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HBV6292 12 X 1 mL
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HBV Seroconversion Panel Donor# 64132 (7 X 1 mL)

HBV6293 7 X 1 mL
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HBV Seroconversion Panel Donor# 66481 (17 X 1 mL)

HBV9072 17 X 1 mL
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HBV9073 16 X 1 mL
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HBV Seroconversion Panel Donor# 66213 (20 X 1 mL)

HBV9074 20 X 1 mL
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HBV Seroconversion Panel Donor# 1034644 (37 X 1 mL)

HBV9092 37 X 1 mL
EUR 2813.09
Description: Please contact Gentaur in order to receive the datasheet of the product.

HBV Seroconversion Panel Donor# 1087380 (31 X 1 mL)

HBV9093 31 X 1 mL
EUR 2701

HBV Seroconversion Panel Donor# 74302 (17 X 1 mL)

HBV9098 17 X 1 mL
EUR 1271

HBV Seroconversion Panel Donor# 75255 (20 X 1 mL)

HBV9099 20 X 1 mL
EUR 1271

Zika Virus Seroconversion Panel (7 X 0.5mL)

KZMC047 7 X 0.5mL
EUR 2890

HIV Seroconversion Panel Donor# 65404 (7 X mL)

HIV9013 7 X mL
EUR 1764

EBV Seroconversion Panel Donor# 283843421 (14 X 1 mL)

EBV9097 14 X 1 mL
EUR 1764

HCV Seroconversion Panel Donor# 69089 (10 X 1 mL)

HCV10000 10 X 1 mL
EUR 1101

HCV Seroconversion Panel Donor# 69654 (7 X 1 mL)

HCV10002 7 X 1 mL
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HCV Seroconversion Panel Donor# 69158 (13 X 1 mL)

HCV10003 13 X 1 mL
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HCV Seroconversion Panel Donor# 69028 (6 X 1 mL)

HCV10004 6 X 1 mL
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HCV10007 11 X 1 mL
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HCV10010 7 X 1 mL
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  • A mutant type of apolipoprotein E that’s faulty in binding to low density lipoprotein receptors is related to familial sort III hyperlipoproteinemia, a genetic dysfunction characterised by elevated plasma levels of cholesterol and accelerated coronary artery illness. Apolipoprotein E is synthesized in numerous organs, together with liver, mind, spleen, and kidney, and is current in excessive concentrations in interstitial fluid, the place it seems to take part in ldl cholesterol redistribution from cells with extra ldl cholesterol to these requiring ldl cholesterol.

 

  • Apolipo-protein E additionally seems to be concerned within the restore response to tissue harm; for instance, markedly elevated quantities of apolipoprotein E are discovered at websites of peripheral nerve harm and regeneration. Other capabilities of apolipoprotein E, unrelated to lipid transport, have gotten recognized, together with immunoregulation and modulation of cell development and differentiation.

Apolipoprotein E: ldl cholesterol transport protein with increasing function in cell biology.

  1. Establishment and upkeep of the blood system depends on self-renewing hematopoietic stem cells (HSCs) that usually reside in small numbers within the bone marrow area of interest of grownup mammals. This Review describes the developmental origins of HSCs and the molecular mechanisms that regulate lineage-specific differentiation.

anti- IL-17 antibody

FNab04224 100µg
EUR 658.5
Description: Antibody raised against IL-17

anti- IL-17 antibody

FNab04225 100µg
EUR 606.3
Description: Antibody raised against IL-17

Anti-IL-17 Antibody

ER1706-91 100ul
EUR 189
Description: Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.

Anti-IL-17 antibody

PAab04224 100 ug
EUR 463.2

Anti-Human IL-17 receptor Antibody

101-M484 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Human IL-17 protein

PRP100289-100ug 100 μg
EUR 1029
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100289-1mg 1 mg
EUR 7139
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100289-5ug 5 μg
EUR 149
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100290-100ug 100 μg
EUR 1029
Description: Human IL-17 protein, expressed in CHO Stable Cells

Human IL-17 protein

PRP100290-1mg 1 mg
EUR 6249
Description: Human IL-17 protein, expressed in CHO Stable Cells

Human IL-17 protein

PRP100290-5ug 5 μg
EUR 129
Description: Human IL-17 protein, expressed in CHO Stable Cells

Recombinant Human IL-17

HEILP-1702 5ug Ask for price

Recombinant Human IL-17

SJB09-03 25µg/vial
EUR 307.2

Anti-Mouse IL-17 Antibody

103-M411 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Anti-IL-17 alpha antibody

STJ93683 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-17Ralpha.

Anti-Human IL-17 (IL-17A) Goat Polyclonal Antibody

TA328238 100 µg Ask for price

Rabbit anti-IL-17 Antibody

DL90598A-100ul 100 ul
EUR 299
Description: CTLA8; IL17; Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Rabbit anti-IL-17 Antibody

DL90598A-50ul 50 ul
EUR 209.3
Description: CTLA8; IL17; Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Rabbit anti-IL-17 Antibody

YLD4293-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IL-17

Rabbit anti-IL-17 Antibody

YLD4293-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IL-17

Anti-Human IL-17 (IL-17A) Rabbit Polyclonal Antibody

TA328239 100 µg Ask for price

Human Interleukin 17 (IL-17) CLIA Kit

abx195860-96tests 96 tests
EUR 990

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-24Tests 24 Tests
EUR 180
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-48Tests 48 Tests
EUR 546
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests 96 Tests
EUR 682
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human Interleukin 17,IL-17 ELISA Kit

201-12-0143 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human IL-17 (Interleukin 17) ELISA Kit

EKE60099-5x96T 5x96T
EUR 2667.6

Human IL-17 (Interleukin 17) ELISA Kit

EKE60099-96T 96T
EUR 561.6

Human Interleukin 17(IL-17) Elisa Kit

EK711084 96 Wells
EUR 0.14

Human IL-17(Interleukin 17) ELISA Kit

E39EH3267 96T
EUR 595

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H1 96T
EUR 520.8

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H2 48T
EUR 340.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-48T 48T
EUR 346.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-96T 96T
EUR 559.2

Human Interleukin 17(IL-17) ELISA Kit

NSL1920Hu 96 wells
EUR 468

Human Interleukin 17(IL-17)ELISA Kit

QY-E04323 96T
EUR 433.2

Human Interleukin 17,IL-17 ELISA Kit

SL0978Hu 96 Tests
EUR 468

Human Interleukin 17,IL-17 ELISA Kit

YLA1538HU-48T 48T Ask for price

Human Interleukin 17,IL-17 ELISA Kit

YLA1538HU-96T 96T Ask for price

Human Interleukin-17 (IL-17) ELISA Kit

IHUIL17KT each
EUR 702
Description: Human Interleukin-17 (IL-17) ELISA Kit

Human IL-17 /IL-17A ELISA kit

E22-HC170.48 48T
EUR 295

Human IL-17 /IL-17A ELISA kit

E22-HC170.96 96T
EUR 395

Recombinant Human Interleukin-17(rHu IL-17)

70117 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of > 1.3 × 105 IU/mg.

IL-17 Interleukin-17 Human Recombinant Protein

PROTQ16552-1 Regular: 25ug
EUR 380.4
Description: Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa.  ;The IL-17 is purified by proprietary chromatographic techniques.

Recombinant Human IL-17 (IL-17A) Protein

PROTQ16552-4 25ug
EUR 380.4
Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.

Anti-Human IL-17 (CTLA-8) Antibody

101-M783 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

human IL-17, His tag

E410A10-100 100μg
EUR 700
Description: Inflammation Storm Cytokine

Human IL-17 ELISA Kit

E16HE0054 96T
EUR 733.33

Human IL-17 ELISA KIT

E16HE0054-048 48 wells
EUR 295

Human IL-17 ELISA KIT

E16HE0054-096 96 wells
EUR 395

IL-17 ELISA KIT|Human

EF006939 96 Tests
EUR 826.8

Human IL-17 ELISA KIT

E42EH-11 96T/48T Ask for price

IL-17 (Human) ELISA Kit

E4628-100 each
EUR 874.8

Human IL-17 ELISA Kit

GWB-ZZD054 1x96 well plate Ask for price

Human IL-17 ELISA kit

LF-EK50201 1×96T
EUR 777.6

Human IL-17 ELISA Kit

RK00397 96 Tests
EUR 280

Human IL-17 GENLISA ELISA

KBH0142 1 x 96 wells
EUR 286

Biotinylated Anti-Human IL-17 (IL-17A) Goat Polyclonal Antibody

TA328237 50 µg Ask for price

Biotinylated Anti-Human IL-17 (IL-17A) Rabbit Polyclonal Antibody

TA328236 50 µg Ask for price

CLIA kit for Human IL-17 (Interleukin 17)

E-CL-H0104 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human IL-17 (Interleukin 17)

E-EL-H0105 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

Human Interleukin 17 (IL-17) Detection Assay Kit

6808 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

IL-17 Interleukin-17 Human Recombinant Protein, HEK

PROTQ16552 Regular: 10ug
EUR 380.4
Description: IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.;The IL-17 is purified by proprietary chromatographic techniques.

Rat Anti-Mouse IL-17, Antibody

GWB-47F187 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-58C273 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-1DEA14 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-F6EA7C 0.5 mg Ask for price

Anti-Mouse IL-17 receptor Antibody

103-M245 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Rat Monoclonal anti-mouse IL-17

mAP-0262 100ug
EUR 250

Interleukin 17 (IL-17) Antibody

abx234224-100ug 100 ug
EUR 610.8

Interleukin 17 (IL-17) Antibody

abx234225-100ug 100 ug
EUR 577.2

IL-17/Interleukin-17, Antibody

GWB-F0E090 1 ml Ask for price

IL-17 Antibody

24784-100ul 100ul
EUR 468
  1. Studies of hematopoiesis present crucial insights of common relevance to different areas of stem cell biology together with the function of mobile interactions in improvement and tissue homeostasis, lineage programming and reprogramming by transcription elements, and stage- and age-specific variations in mobile phenotypes.

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